SCHEMBL16201558

SCHEMBL16201558

Cc1cccc(C2=CC(c3cccc(C)c3)CC(C#N)=C2)c1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 2/20 0.35
AR P10275 1/20 0.35
HTR2C P28335 3/20 0.33
NISCH Q9Y2I1 1/20 0.33
ALDH1A1 P00352 3/20 0.32
NPC1 O15118 3/20 0.32
HPGD P15428 3/20 0.32
RAB9A P51151 3/20 0.32
SMN1; SMN2 Q16637 3/20 0.32
KDM4E B2RXH2 2/20 0.32
LMNA P02545 1/20 0.32
ADORA2A P29274 1/20 0.32
ADORA1 P30542 1/20 0.32
CTSS P25774 1/20 0.32
CTSK P43235 1/20 0.32
KMT2A Q03164 2/20 0.32
TSHR P16473 2/20 0.32
MAPK1 P28482 1/20 0.32
HSD17B10 Q99714 1/20 0.32
MEN1 O00255 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23959430 0.82 NISCH (0.38) ARNISCHALDH1A1NPC1HPGD
SCHEMBL24648589 0.79 CFTR (0.33)
SCHEMBL21698968 0.68 MAOA (0.37) MAOBNISCHALDH1A1NPC1HPGD
SCHEMBL23335819 0.67 AR (0.38) ARNISCHALDH1A1NPC1HPGD
SCHEMBL31220896 0.61 TDP1 (0.43) MAOBHTR2CALDH1A1LMNAKMT2A
SCHEMBL7386770 0.60 CLK4 (0.53) MAOBARALDH1A1HPGDSMN1; SMN2
SCHEMBL31471473 0.59 ACHE (0.69) ARNISCHALDH1A1NPC1HPGD
SCHEMBL29373699 0.59 ACHE (0.69) ARNISCHALDH1A1NPC1HPGD
SCHEMBL301247 0.59 ACHE (0.69) ARNISCHALDH1A1NPC1HPGD
SCHEMBL6110387 0.58 AR (0.54) ARALDH1A1SLC6A4SLC6A3KDM1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20140319507-A1 Organic Electroluminescent Element, Material for Organic Electroluminescent Element, Light Emitting Device, Display Device and Lighting Device Each Using Said Element, and Compound Used for Said Element UDC IRELAND LIMITED (IE) 2014-10-30 US disclosed