Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.44 |
| ▸ | HTR7 | P34969 | 2/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.43 |
| ▸ | METAP1 | P53582 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.38 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 2/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16201916 | 0.90 | HTR1A (0.43) | HTR1AHTR7CYP19A1METAP1PTPN5 | |
| SCHEMBL16201908 | 0.89 | HTR1A (0.47) | HTR1AHTR7CYP19A1MAPTS1PR5 | |
| SCHEMBL16775649 | 0.87 | MAOB (0.43) | HTR1AHTR7CYP19A1METAP1S1PR5 | |
| SCHEMBL16193624 | 0.86 | CFTR (0.45) | HTR1AHTR7CYP19A1S1PR5MEN1 | |
| SCHEMBL16201915 | 0.85 | HTR1A (0.41) | HTR1AHTR7CYP19A1METAP1S1PR5 | |
| SCHEMBL16193531 | 0.85 | MAPK14 (0.46) | HTR1AHTR7CYP19A1MAPTS1PR5 | |
| SCHEMBL16201917 | 0.84 | CYP19A1 (0.42) | HTR1AHTR7CYP19A1MAPTGRM5 | |
| SCHEMBL16201909 | 0.83 | CYP19A1 (0.50) | CYP19A1MEN1KMT2AMAOB | |
| SCHEMBL16201913 | 0.83 | HTR1A (0.41) | HTR1AHTR7CYP19A1METAP1MAPT | |
| SCHEMBL16775661 | 0.82 | GPR52 (0.46) | HTR1AHTR7CYP19A1METAP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9415027-B2 | Therapeutic agents | ALLERGAN, INC. (US) | 2016-08-16 | — | — | US | disclosed |
| US-20150258048-A1 | THERAPEUTIC AGENTS | ALLERGAN, INC. | 2015-09-17 | — | — | US | disclosed |
| US-9051294-B2 | Therapeutic agents | ALLERGAN, INC. (US) | 2015-06-09 | — | — | US | disclosed |
| US-20140323558-A1 | THERAPEUTIC AGENTS | ALLERGAN, INC. (US) | 2014-10-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140323558-A1 | THERAPEUTIC AGENTS | PTGER4, PTGER2, PTGER1 | HTR1A 503/4885HTR7 669/4885CYP19A1 2330/4885 |
| US-20150258048-A1 | THERAPEUTIC AGENTS | PTGER4, PTGER2, PTGER1 | HTR1A 503/4885HTR7 669/4885CYP19A1 2330/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.