Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | HTR1B | P28222 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1619062 | 0.86 | HRH3 (0.43) | KDM4EALDH1A1MEN1KMT2ATDP1 | |
| SCHEMBL1619357 | 0.82 | HRH3 (0.48) | KDM4EALDH1A1MEN1KMT2AHTT | |
| SCHEMBL1619395 | 0.81 | HRH3 (0.45) | KDM4EALDH1A1KDM1AHTTPOLB | |
| SCHEMBL4125532 | 0.80 | KDM4E (0.55) | KDM4EALDH1A1MEN1KMT2ATDP1 | |
| SCHEMBL1619052 | 0.79 | HRH3 (0.48) | KDM4EALDH1A1MEN1KMT2AHTT | |
| SCHEMBL1619360 | 0.78 | KCNH2 (0.39) | KDM4EALDH1A1MEN1KMT2ATDP1 | |
| SCHEMBL1618885 | 0.74 | KCNH2 (0.41) | KDM4EALDH1A1MEN1KMT2APOLB | |
| SCHEMBL1619503 | 0.73 | HRH3 (0.44) | KDM4EALDH1A1MEN1KMT2ATDP1 | |
| SCHEMBL3123075 | 0.71 | S1PR1 (0.41) | MEN1KMT2AHTTLMNA | |
| SCHEMBL1619682 | 0.70 | KCNH2 (0.45) | KDM4EALDH1A1MEN1TDP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7928225-B2 | Oxabispidine compounds for the treatment of cardiac arrhythmias | ASTRAZENECA AB (SE) | 2011-04-19 | — | — | US | disclosed |