Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH5A1 | P51649 | 2/20 | 0.38 |
| ▸ | ABAT | P80404 | 2/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.32 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.32 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.32 |
| ▸ | XDH | P47989 | 1/20 | 0.32 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
| ▸ | NQO2 | P16083 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA3 | P07451 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3288586 | 0.84 | EGFR (0.35) | KDM4EPTGS2RAB9AEGFRALDH1A1 | |
| SCHEMBL3637772 | 0.79 | EGFR (0.41) | ALDH5A1ABATLCKKDM4EPTGS2 | |
| SCHEMBL9261197 | 0.77 | LCK (0.58) | ALDH5A1ABATLCKKDM4EPTGS2 | |
| SCHEMBL4575600 | 0.77 | ALDH5A1 (0.52) | ALDH5A1ABATLCKKDM4EPTGS2 | |
| SCHEMBL718437 | 0.77 | BACE1 (0.50) | LCKEGFRALDH1A1HPGDCA12 | |
| SCHEMBL2807680 | 0.77 | BACE1 (0.41) | LCKALDH1A1HPGDCA12CA1 | |
| SCHEMBL37131 | 0.77 | LCK (0.58) | ALDH5A1ABATLCKKDM4EPTGS2 | |
| SCHEMBL24216635 | 0.75 | HSD17B10 (0.38) | EGFRALDH1A1HSD17B10 | |
| SCHEMBL31653367 | 0.75 | EGFR (0.32) | EGFR | |
| SCHEMBL30460212 | 0.75 | HSD17B10 (0.38) | EGFRALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9878045-B2 | Triorthogonal reagents for dual protein conjugation | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2018-01-30 | — | — | US | disclosed |
| US-9878045-B2 | Triorthogonal reagents for dual protein conjugation | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2018-01-30 | — | — | US | disclosed |
| US-9878045-B2 | Triorthogonal reagents for dual protein conjugation | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2018-01-30 | — | — | US | disclosed |
| US-20160271261-A1 | TRIORTHOGONAL REAGENTS FOR DUAL PROTEIN CONJUGATION | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2016-09-22 | — | — | US | disclosed |
| US-20160271261-A1 | TRIORTHOGONAL REAGENTS FOR DUAL PROTEIN CONJUGATION | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2016-09-22 | — | — | US | disclosed |
| US-20160271261-A1 | TRIORTHOGONAL REAGENTS FOR DUAL PROTEIN CONJUGATION | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2016-09-22 | — | — | US | disclosed |
| WO-2015057863-A1 | TRIORTHOGONAL REAGENTS FOR DUAL PROTEIN CONJUGATION | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2015-04-23 | — | — | WO | disclosed |
| WO-2015057863-A1 | TRIORTHOGONAL REAGENTS FOR DUAL PROTEIN CONJUGATION | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 2015-04-23 | — | — | WO | disclosed |
| EP-2194046-B1 | Triazolone derivative | EISAI R&D MAN CO LTD (JP) | 2012-05-09 | — | — | EP | disclosed |
| US-8163787-B2 | Triazolone derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2012-04-24 | — | — | US | disclosed |
| US-20110112109-A1 | TRIAZOLONE DERIVATIVES | CLARK RICHARD | 2011-05-12 | — | — | US | disclosed |
| US-7928228-B2 | Triazolone derivatives | EISAI CO., LTD. (JP) | 2011-04-19 | — | — | US | disclosed |
| US-7816522-B2 | Triazolone derivatives | EISAI CO., LTD. (JP) | 2010-10-19 | — | — | US | disclosed |
| US-20100190783-A1 | TRIAZOLONE DERIVATIVES | CLARK RICHARD | 2010-07-29 | — | — | US | disclosed |
| EP-2194046-A1 | Triazolone derivative | Eisai R&D Management Co., Ltd. (JP) | 2010-06-09 | — | — | EP | disclosed |
| CN-101405275-A | Triazolone Derivatives | EISAI R&D MAN CO LTD (JP) | 2009-04-08 | — | — | CN | disclosed |
| EP-2000465-A1 | TRIAZOLONE DERIVATIVE | Eisai R&D Management Co., Ltd. (JP) | 2008-12-10 | — | — | EP | disclosed |
| US-20080015199-A1 | Triazolone derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2008-01-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100190783-A1 | TRIAZOLONE DERIVATIVES | H1-0, H1-10, H1-2 | ALDH5A1 1553/4885ABAT 4222/4885LCK 3471/4885 |
| US-20110112109-A1 | TRIAZOLONE DERIVATIVES | H1-10, H1-0, H1-2 | ALDH5A1 1582/4885ABAT 4040/4885LCK 3613/4885 |
| US-20160271261-A1 | TRIORTHOGONAL REAGENTS FOR DUAL PROTEIN CONJUGATION | FNTA, FNTB, GNPAT | ALDH5A1 1067/4885ABAT 963/4885LCK 2789/4885 |
| US-20080015199-A1 | Triazolone derivatives | F3, F12, F2 | ALDH5A1 1875/4885ABAT 3701/4885LCK 3482/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.