Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 16/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL973233 | 0.85 | HSD11B1 (0.48) | HSD11B1 | |
| SCHEMBL16208130 | 0.84 | HSD11B1 (0.37) | HSD11B1 | |
| SCHEMBL16208217 | 0.79 | HSD11B1 (0.36) | HSD11B1EPHX2BACE1CNR1CNR2 | |
| SCHEMBL16208160 | 0.76 | HSD11B1 (0.49) | HSD11B1 | |
| SCHEMBL16207937 | 0.74 | HSD11B1 (0.62) | HSD11B1EPHX2 | |
| SCHEMBL16208191 | 0.73 | NAMPT (0.42) | — | |
| SCHEMBL975332 | 0.73 | CNR2 (0.45) | HSD11B1EPHX2CNR2 | |
| SCHEMBL16208093 | 0.72 | HSD11B1 (0.47) | HSD11B1CNR2 | |
| SCHEMBL16208070 | 0.72 | HSD11B1 (0.49) | HSD11B1 | |
| SCHEMBL16208051 | 0.70 | HSD11B1 (0.51) | HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2238126-B1 | DERIVATIVES OF TETRAHYDROQUINOXALINE UREA, PREPARATION THEREOF AND THERAPEUTIC APPLICATION THEREOF | SANOFI SA (FR) | 2014-11-05 | — | — | EP | claimed |