Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 1/20 | 0.52 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.45 |
| ▸ | TOP2A | P11388 | 1/20 | 0.45 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6203393 | 0.74 | DDB1 (0.64) | DDB1CRBNHPGDHDAC6TOP2A | |
| SCHEMBL2297677 | 0.70 | HPGD (0.62) | DDB1CRBNHPGDPOLBMEN1 | |
| SCHEMBL10742560 | 0.70 | CYP1A2 (0.68) | DDB1CRBNHPGDPOLBMEN1 | |
| SCHEMBL5911725 | 0.70 | DDB1 (0.55) | DDB1CRBNHPGDPOLBMEN1 | |
| SCHEMBL5762322 | 0.70 | RAB9A (0.54) | DDB1CRBNHPGDHDAC6TOP2A | |
| SCHEMBL28234149 | 0.70 | RAB9A (0.61) | DDB1CRBNMEN1KMT2AMAPT | |
| SCHEMBL14398876 | 0.69 | MAPT (0.41) | DDB1CRBNHPGDHDAC6TOP2A | |
| SCHEMBL1318504 | 0.69 | HPGD (0.60) | HPGDPOLBMEN1KMT2AGAA | |
| SCHEMBL14505992 | 0.69 | HPGD (0.60) | HPGDPOLBMEN1KMT2AGAA | |
| SCHEMBL19585683 | 0.69 | CRBN (1.00) | DDB1CRBNHPGDHDAC6TOP2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2480531-B1 | PYRROLIDINONE CARBOXAMIDE DERIVATIVES AS CHEMERIN-R (CHEMR23) MODULATORS | CHEMOCENTRYX INC (US) | 2014-11-05 | — | — | EP | disclosed |