Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.36 |
| ▸ | SCD5 | Q86SK9 | 7/20 | 0.35 |
| ▸ | SCD | O00767 | 6/20 | 0.35 |
| ▸ | PROKR1 | Q8TCW9 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | SPR | P35270 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16212231 | 0.84 | FFAR1 (0.35) | FFAR1S1PR2LMNA | |
| SCHEMBL23089202 | 0.80 | PROKR1 (0.49) | SCD5SCDPROKR1 | |
| SCHEMBL15535023 | 0.77 | MEN1 (0.42) | TP53MAPT | |
| SCHEMBL25255898 | 0.76 | SCD5 (0.38) | SCD5SCDPROKR1LMNATP53 | |
| SCHEMBL16211755 | 0.75 | MAP3K12 (0.39) | PROKR1LMNASPR | |
| SCHEMBL162009 | 0.75 | NAPRT (0.43) | SMN1; SMN2TDP1 | |
| SCHEMBL23453444 | 0.74 | SMN1; SMN2 (0.49) | PROKR1LMNATP53MAPTNPC1 | |
| SCHEMBL16212243 | 0.73 | MAP3K12 (0.37) | PROKR1HSD11B1 | |
| SCHEMBL15535084 | 0.73 | PROKR1 (0.43) | PROKR1LMNASPRSMN1; SMN2HSD11B1 | |
| SCHEMBL18585817 | 0.72 | HSD11B1 (0.53) | LMNATP53MAPTSPRNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2991978-A1 | BIHETEROARYL COMPOUNDS AND USES THEREOF | F. Hoffmann-La Roche SA (CH) | 2016-03-09 | — | — | EP | disclosed |
| WO-2014177060-A1 | BIHETEROARYL COMPOUNDS AND USES THEREOF | F.HOFFMANN-LA ROCHE AG (CH) | 2014-11-06 | — | — | WO | disclosed |