Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.50 |
| ▸ | PKM | P14618 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19392455 | 0.77 | MEN1 (0.61) | ALDH1A1PKMSMN1; SMN2MEN1KMT2A | |
| SCHEMBL9271788 | 0.77 | ALDH1A1 (0.56) | ALDH1A1PKMSMN1; SMN2MEN1KMT2A | |
| SCHEMBL16213694 | 0.73 | ALDH1A1 (0.54) | ALDH1A1SMN1; SMN2MAPK1NPC1HPGD | |
| SCHEMBL28859611 | 0.72 | ALDH1A1 (0.63) | ALDH1A1MEN1KMT2ANPC1LMNA | |
| SCHEMBL20730795 | 0.70 | ALDH1A1 (0.77) | ALDH1A1PKMSMN1; SMN2MEN1KMT2A | |
| SCHEMBL8079254 | 0.69 | ALDH1A1 (0.58) | ALDH1A1PKMSMN1; SMN2MAPK1KDM4E | |
| SCHEMBL5599840 | 0.68 | MEN1 (0.66) | ALDH1A1MEN1KMT2AHPGDLMNA | |
| SCHEMBL1859957 | 0.68 | CA1 (0.62) | ALDH1A1SMN1; SMN2KDM4ENPC1HPGD | |
| SCHEMBL31553561 | 0.68 | MMP12 (0.39) | ALDH1A1SMN1; SMN2HTT | |
| SCHEMBL31553562 | 0.68 | MMP12 (0.39) | ALDH1A1SMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2718280-B1 | COMPOUNDS HAVING MUSCARINIC RECEPTOR ANTAGONIST AND BETA2 ADRENERGIC RECEPTOR AGONIST ACTIVITY | CHIESI FARMA SPA (IT) | 2015-09-16 | — | — | EP | disclosed |
| US-8877774-B2 | Compounds having muscarinic receptor antagonist and beta2 Adrenergic receptor agonist activity | CHIESI FARMACEUTICI S.P.A. (IT) | 2014-11-04 | — | — | US | disclosed |
| US-8877774-B2 | Compounds having muscarinic receptor antagonist and beta2 Adrenergic receptor agonist activity | CHIESI FARMACEUTICI S.P.A. (IT) | 2014-11-04 | — | — | US | disclosed |