Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15442499 | 0.80 | CYP2C19 (0.39) | CYP2C19MEN1GLAKMT2ACYP1A2 | |
| SCHEMBL13185663 | 0.78 | CYP2C19 (0.38) | LMNACYP2C19MEN1GLAKMT2A | |
| SCHEMBL12283218 | 0.78 | — | — | |
| SCHEMBL16213683 | 0.76 | LMNA (0.38) | LMNATHRB | |
| SCHEMBL16213675 | 0.76 | LMNA (0.30) | LMNA | |
| SCHEMBL10282742 | 0.75 | — | — | |
| SCHEMBL11310928 | 0.74 | CYP2C19 (0.35) | LMNACYP2C19MEN1GLAKMT2A | |
| SCHEMBL14418739 | 0.73 | LMNA (0.35) | LMNATHRB | |
| SCHEMBL7879498 | 0.72 | — | — | |
| SCHEMBL12526924 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8877774-B2 | Compounds having muscarinic receptor antagonist and beta2 Adrenergic receptor agonist activity | CHIESI FARMACEUTICI S.P.A. (IT) | 2014-11-04 | — | — | US | disclosed |