⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7967935 | 0.98 | PKM (0.64) | — | |
| SCHEMBL8682418 | 0.82 | PKM (0.72) | — | |
| SCHEMBL7962955 | 0.80 | — | — | |
| SCHEMBL5725392 | 0.80 | — | — | |
| SCHEMBL192563 | 0.80 | — | — | |
| Benzene SCHEMBL28205648 | 0.78 | KDM4E (0.96) | — | |
| Hydrochloric Acid SCHEMBL8624744 | 0.78 | KDM4E (0.96) | — | |
| SCHEMBL1667399 | 0.78 | — | — | |
| Bromide SCHEMBL27963333 | 0.78 | KDM4E (0.96) | — | |
| SCHEMBL29015082 | 0.77 | PKM (0.70) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 56 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100482650-C | Process of synthesizing 4-methyl-5-formyl thiazole | UNIV TSINGHUA (CN) | 2009-04-29 | — | — | CN | claimed |
| CN-101020668-A | Process of synthesizing 4-methyl-5-formyl thiazole | UNIV TSINGHUA (CN) | 2007-08-22 | — | — | CN | claimed |
| CN-118271285-A | Azetidine-containing amide derivative, preparation method and application thereof | 贵州大学 | 2024-07-02 | — | — | CN | disclosed |
| US-10668051-B2 | Modulators of calcium release-activated calcium channel | RHIZEN PHARMACEUTICALS SA (CH) | 2020-06-02 | — | — | US | disclosed |
| US-20190160046-A1 | NOVEL MODULATORS OF CALCIUM RELEASE-ACTIVATED CALCIUM CHANNEL | RHIZEN PHARMACEUTICALS AG (CH) | 2019-05-30 | — | — | US | disclosed |
| US-10246450-B2 | Modulators of calcium release-activated calcium channel | RHIZEN PHARMACEUTICALS SA (CH) | 2019-04-02 | — | — | US | disclosed |
| US-20180222898-A1 | NOVEL MODULATORS OF CALCIUM RELEASE-ACTIVATED CALCIUM CHANNEL | RHIZEN PHARMACEUTICALS AG (CH) | 2018-08-09 | — | — | US | disclosed |
| EP-2509955-B1 | PYRAZOLE DERIVATIVES AS MODULATORS OF CALCIUM RELEASE-ACTIVATED CALCIUM CHANNEL | RHIZEN PHARMACEUTICALS S A (CH) | 2018-04-25 | — | — | EP | disclosed |
| US-9944631-B2 | Modulators of calcium release-activated calcium channel | RHIZEN PHARMACEUTICALS SA (CH) | 2018-04-17 | — | — | US | disclosed |
| EP-3299361-A1 | PYRAZOLE DERIVATIVES AS MODULATORS OF CALCIUM RELEASE-ACTIVATED CALCIUM CHANNEL | Rhizen Pharmaceuticals S.A. (CH) | 2018-03-28 | — | — | EP | disclosed |
| US-20170313690-A1 | NOVEL MODULATORS OF CALCIUM RELEASE-ACTIVATED CALCIUM CHANNEL | RHIZEN PHARMACEUTICALS AG (CH) | 2017-11-02 | — | — | US | disclosed |
| US-20010031760-A1 | Method of treating a patient having precancerous lesions with quinazoline derivatives | PAMUKCU RIFAT (US) | 2001-10-18 | — | — | US | disclosed |
| US-6262059-B1 | Method of treating a patient having precancerous lesions with quinazoline derivatives | CELL PATHWAYS, INC. | 2001-07-17 | — | — | US | disclosed |
| US-5728869-A | Processes for the preparation of pesticides and intermediates | AMERICAN CYANAMID COMPANY (US) | 1998-03-17 | — | — | US | disclosed |
| US-5521317-A | Processes for the preparation of pesticides and intermediates | AMERICAN CYANAMID CO. (US) | 1996-05-28 | — | — | US | disclosed |
| EP-0654464-A1 | Processes for the preparation of pesticides and intermediates | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1995-05-24 | — | — | EP | disclosed |
| US-5136042-A | PROCESS FOR THE PREPARATION OF THIAZOLECARBOXYLIC ACID CHLORIDES | MITSUI TOATSU CHEMICALS, INC. (JP) | 1992-08-04 | — | — | US | disclosed |
| EP-0377750-A1 | PROCESS FOR PREPARING THIAZOLECARBOXYLIC ACID CHLORIDES | MITSUI CHEMICALS, INC. (JP) | 1990-07-18 | — | — | EP | disclosed |
| US-4001237-A | HYPOTENSIVES | BRISTOL-MYERS COMPANY (US) | 1977-01-04 | — | — | US | disclosed |
| US-3961067-A | Composition comprising a benzenesulfonylurea hypoglycemic agent and method of treatment | PFIZER INC. (US) | 1976-06-01 | — | — | US | disclosed |