SCHEMBL16213850

SCHEMBL16213850

CCc1nc(N)nc(Nc2cccc(S(=O)(=O)O)c2)n1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 6/20 0.51
RAB9A P51151 6/20 0.51
NOD1 Q9Y239 2/20 0.51
POLB P06746 3/20 0.48
MAPT P10636 6/20 0.45
HTT P42858 3/20 0.45
KMT2A Q03164 2/20 0.45
PDE4B Q07343 3/20 0.44
PDE4D Q08499 2/20 0.44
USP2 O75604 2/20 0.44
MEN1 O00255 1/20 0.44
RECQL P46063 1/20 0.44
L3MBTL1 Q9Y468 2/20 0.43
JAK2 O60674 1/20 0.43
TNF P01375 1/20 0.43
MAPK1 P28482 1/20 0.43
LMNA P02545 1/20 0.42
TP53 P04637 1/20 0.42
SLC29A2 Q14542 1/20 0.42
SLC29A1 Q99808 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17033128 0.89 NPC1 (0.47) NPC1RAB9ANOD1POLBMAPT
SCHEMBL16213857 0.86 PDE4B (0.43) NPC1RAB9APDE4BPDE4DJAK2
SCHEMBL16213862 0.86 SNCA (0.50) PDE4BPDE4D
SCHEMBL17033141 0.84 NPC1 (0.43) NPC1RAB9ANOD1POLBMAPT
SCHEMBL15984406 0.83 CA1 (0.54) NPC1RAB9ANOD1MAPTLMNA
SCHEMBL5528958 0.83 IDH2 (0.45) POLBKMT2APDE4BPDE4DALDH1A1
SCHEMBL14817410 0.82 CA12 (0.44) NPC1RAB9ANOD1MAPTJAK2
SCHEMBL14817406 0.82 CA9 (0.55) USP2ALDH1A1TDP1ROCK1
SCHEMBL16213845 0.81 KCNH3 (0.41) PDE4BPDE4DRECQL
SCHEMBL15984410 0.81 KCNH3 (0.55)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8876915-B2 Coloring composition and ink for inkjet recording FUJIFILM CORPORATION (JP) 2014-11-04 US disclosed