Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 6/20 | 0.67 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | PDE2A | O00408 | 2/20 | 0.44 |
| ▸ | DAO | P14920 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | AGXT | P21549 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MPL | P40238 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARD | Q03181 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | NAAA | Q02083 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13756283 | 0.86 | IDO1 (0.51) | IDO1AGXTRAB9ANAAAAPP | |
| SCHEMBL20665618 | 0.85 | IDO1 (0.49) | IDO1FFAR1CYP1A2AGXT | |
| SCHEMBL12903738 | 0.83 | IDO1 (0.46) | IDO1FFAR1PDE2ADAOSLC6A4 | |
| SCHEMBL25735766 | 0.81 | IDO1 (0.46) | IDO1DAOSLC6A4CYP1A2 | |
| SCHEMBL12516416 | 0.81 | IDO1 (0.67) | IDO1FFAR1PDE2ADAOSLC6A4 | |
| SCHEMBL12964490 | 0.81 | IDO1 (0.61) | IDO1FFAR1PDE2ADAOSLC6A4 | |
| SCHEMBL16892265 | 0.80 | MBOAT4 (0.46) | IDO1FFAR1SLC6A4CYP1A2RAB9A | |
| SCHEMBL20708934 | 0.80 | PDE2A (0.45) | IDO1PDE2ADAOSLC6A4CYP1A2 | |
| SCHEMBL3877950 | 0.80 | CFTR (0.49) | IDO1SLC6A4SLC6A2SLC6A3CYP1A2 | |
| SCHEMBL3156002 | 0.79 | IDO1 (0.63) | IDO1FFAR1PDE2ADAOSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023121939-A1 | SUBSTITUTED BENZOTHIOPHENE DERIVATIVES AND METHODS OF USE THEREOF | MERCK SHARP & DOHME LLC (US) | 2023-06-29 | — | — | WO | disclosed |
| US-11274101-B2 | Heterocyclic compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2022-03-15 | — | — | US | disclosed |
| US-11242348-B2 | — | — | 2022-02-08 | — | — | US | disclosed |
| US-20200255439-A1 | HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2020-08-13 | — | — | US | disclosed |
| US-8877439-B2 | Method for rapidly evaluating performance of short interfering RNA with novel chemical modifications | SIRNA THERAPEUTICS, INC. (US) | 2014-11-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200255439-A1 | HETEROCYCLIC COMPOUND | MAG, HTT, ACHE | IDO1 1753/4885FFAR1 3822/4885PDE2A 2413/4885 |
| US-11274101-B2 | Heterocyclic compound | MAG, HTT, ACHE | IDO1 1753/4885FFAR1 3822/4885PDE2A 2413/4885 |
| US-11242348-B2 | — | MAG, ACHE, GAP43 | IDO1 1756/4885FFAR1 3510/4885PDE2A 1790/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.