Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | ASGR1 | P07306 | 5/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16217765 | 1.00 | KMT2A (0.60) | KMT2AALDH1A1L3MBTL1PKMASGR1 | |
| SCHEMBL7154618 | 0.88 | KMT2A (0.49) | KMT2AALDH1A1L3MBTL1PKMASGR1 | |
| SCHEMBL16367194 | 0.82 | KMT2A (0.47) | KMT2AALDH1A1L3MBTL1PKMASGR1 | |
| SCHEMBL8823006 | 0.82 | KMT2A (0.47) | KMT2AALDH1A1L3MBTL1PKMASGR1 | |
| SCHEMBL16864092 | 0.82 | KMT2A (0.47) | KMT2AALDH1A1L3MBTL1PKMASGR1 | |
| SCHEMBL2503399 | 0.82 | KMT2A (0.47) | KMT2AALDH1A1L3MBTL1PKMASGR1 | |
| SCHEMBL12391259 | 0.82 | KMT2A (0.47) | KMT2AALDH1A1L3MBTL1PKMASGR1 | |
| SCHEMBL17231142 | 0.81 | ALDH1A1 (0.49) | KMT2AALDH1A1L3MBTL1PKMASGR1 | |
| SCHEMBL2503406 | 0.80 | KMT2A (0.76) | KMT2AALDH1A1L3MBTL1PKMLMNA | |
| SCHEMBL8718037 | 0.80 | KMT2A (0.76) | KMT2AALDH1A1L3MBTL1PKMLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015168618-A2 | COMPOSITIONS AND METHODS FOR MODULATING GROWTH HORMONE RECEPTOR EXPRESSION | ISIS PHARMACEUTICALS, INC. (US) | 2015-11-05 | — | — | WO | disclosed |
| WO-2015042447-A1 | TARGETED THERAPEUTIC NUCLEOSIDES AND THEIR USE | ISIS PHARMACEUTICALS, INC. (US) | 2015-03-26 | — | — | WO | disclosed |
| WO-2014205451-A2 | COMPOSITIONS AND METHODS FOR MODULATION OF TARGET NUCLEIC ACIDS | ISIS PHARMACEUTICALS, INC. (US) | 2014-12-24 | — | — | WO | disclosed |
| WO-2014179620-A1 | CONJUGATED ANTISENSE COMPOUNDS AND THEIR USE | ISIS PHARMACEUTICALS, INC. (US) | 2014-11-06 | — | — | WO | disclosed |
| WO-2014179625-A1 | COMPOSITIONS AND METHODS FOR MODULATING APOLIPOPROTEIN (a) EXPRESSION | ISIS PHARMACEUTICALS, INC. (US) | 2014-11-06 | — | — | WO | disclosed |
| WO-2014179629-A2 | COMPOSITIONS AND METHODS | ISIS PHARMACEUTICALS, INC. (US) | 2014-11-06 | — | — | WO | disclosed |