SCHEMBL16221597

Nc1nc2c(ncn2[C@H]2CC[C@@H](COP(=O)(S)O[C@@H]3C[C@H](n4cnc5c(N)ncnc54)O[C@@H]3COP(=O)(O)S)O2)c(=O)[nH]1

nearest known ligand 0.53

Predicted protein targets (top 10)

	gene	UniProt	supporting neighbours	confidence
▸	POLB	P06746	2/20	0.51

▸	TERT	O14746	1/20	0.49

▸	P2RY2	P41231	1/20	0.45

▸	P2RY4	P51582	1/20	0.45

▸	P2RY6	Q15077	1/20	0.45

▸	ENPP1	P22413	1/20	0.44

▸	P2RY1	P47900	1/20	0.44

▸	STING1	Q86WV6	3/20	0.44

▸	DTYMK	P23919	2/20	0.44

▸	F2	P00734	1/20	0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL20326935	1.00	POLB (0.51)	POLBTERTP2RY2P2RY4P2RY6
SCHEMBL22434567	1.00	POLB (0.51)	POLBTERTP2RY2P2RY4P2RY6
SCHEMBL16221825	0.94	POLB (0.56)	POLBP2RY2P2RY4P2RY6P2RY1
SCHEMBL16217855	0.94	TERT (0.50)	POLBTERTP2RY2P2RY4P2RY6
SCHEMBL24239526	0.94	TERT (0.57)	POLBTERTP2RY2P2RY4P2RY6
SCHEMBL20324708	0.92	POLB (0.48)	POLBTERTP2RY2P2RY4P2RY6
SCHEMBL20324897	0.92	POLB (0.48)	POLBTERTP2RY2P2RY4P2RY6
SCHEMBL20327045	0.92	POLB (0.48)	POLBTERTP2RY2P2RY4P2RY6
SCHEMBL21417214	0.92	POLB (0.47)	POLBTERTSTING1F2
SCHEMBL22352121	0.92	POLB (0.54)	POLBP2RY2ENPP1P2RY1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2014179627-A2	COMPOSITIONS AND METHODS FOR MODULATING HBV AND TTR EXPRESSION	ISIS PHARMACEUTICALS, INC. (US)	2014-11-06	—	—	WO	disclosed