SCHEMBL16217855

Cc1cn(C2C[C@@H](OP(=O)(S)OC[C@H]3O[C@@H](n4cnc5c(N)ncnc54)C[C@H]3OP(=O)(S)OC[C@@H]3CCC(n4cnc5c(=O)[nH]c(N)nc54)O3)[C@@H](COP(=O)(O)S)O2)c(=O)nc1N

nearest known ligand 0.50

Predicted protein targets (top 9)

	gene	UniProt	supporting neighbours	confidence
▸	TERT	O14746	1/20	0.50

▸	POLB	P06746	2/20	0.46

▸	DTYMK	P23919	4/20	0.46

▸	F2	P00734	2/20	0.46

▸	FUT5	Q11128	1/20	0.41

▸	P2RY2	P41231	1/20	0.41

▸	P2RY4	P51582	1/20	0.41

▸	P2RY6	Q15077	1/20	0.41

▸	P2RY1	P47900	1/20	0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL16221824	0.96	POLB (0.50)	TERTPOLBF2FUT5P2RY2
SCHEMBL18158912	0.96	POLB (0.50)	TERTPOLBF2FUT5P2RY2
SCHEMBL22434567	0.94	POLB (0.51)	TERTPOLBDTYMKF2P2RY2
SCHEMBL20326935	0.94	POLB (0.51)	TERTPOLBDTYMKF2P2RY2
SCHEMBL16221597	0.94	POLB (0.51)	TERTPOLBDTYMKF2P2RY2
SCHEMBL16410980	0.94	POLB (0.47)	POLBDTYMKP2RY1
SCHEMBL24239526	0.93	TERT (0.57)	TERTPOLBDTYMKF2P2RY2
SCHEMBL16221825	0.89	POLB (0.56)	POLBF2FUT5P2RY2P2RY4
SCHEMBL18158882	0.88	DTYMK (0.58)	TERTPOLBDTYMKF2
SCHEMBL24239532	0.88	DTYMK (0.58)	TERTPOLBDTYMKF2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2014179626-A2	COMPOSITIONS AND METHODS FOR MODULATING APOLIPOPROTEIN C-III EXPRESSION	ISIS PHARMACEUTICALS, INC. (US)	2014-11-06	—	—	WO	disclosed