Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | BACE1 | P56817 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PDE1A | P54750 | 2/20 | 0.39 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.39 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5703818 | 0.89 | MEN1 (0.51) | MEN1KMT2ABACE1KDM4E | |
| SCHEMBL5703835 | 0.88 | MEN1 (0.45) | MEN1KMT2ABACE1KDM4E | |
| SCHEMBL8976312 | 0.87 | ALOX15 (0.52) | MEN1KMT2ABACE1KDM4EPOLB | |
| SCHEMBL4583951 | 0.85 | KMT2A (0.54) | MEN1KMT2AKDM4EPOLBPDE1A | |
| SCHEMBL4583955 | 0.85 | KMT2A (0.54) | MEN1KMT2AKDM4EPOLBPDE1A | |
| SCHEMBL6804331 | 0.82 | HDAC3 (0.46) | MEN1KMT2AKDM4EPOLBPDE1A | |
| SCHEMBL1625900 | 0.80 | BACE1 (0.47) | MEN1KMT2ABACE1KDM4EALDH1A1 | |
| SCHEMBL1625898 | 0.80 | BACE1 (0.47) | MEN1KMT2ABACE1KDM4EALDH1A1 | |
| SCHEMBL18290080 | 0.79 | SSTR4 (0.45) | KDM4EPOLBPDE1APDE1BPDE1C | |
| SCHEMBL18290020 | 0.77 | CA14 (0.40) | KDM4EPOLBPDE1APDE1BPDE1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7928264-B2 | Aminoalcohol derivatives | ASTELLAS PHARMA INC. (JP) | 2011-04-19 | — | — | US | disclosed |
| EP-1697301-A2 | AMINOALCOHOL DERIVATIVES | Astellas Pharma Inc. (JP) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005061433-A2 | AMINOALCOHOL DERIVATIVES | ASTELLAS PHARMA INC. (JP) | 2005-07-07 | — | — | WO | disclosed |