Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | LTB4R | Q15722 | 7/20 | 0.44 |
| ▸ | LTB4R2 | Q9NPC1 | 7/20 | 0.44 |
| ▸ | BACE1 | P56817 | 5/20 | 0.42 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1622181 | 0.87 | MEN1 (0.50) | ALOX15MEN1KMT2ABACE1KDM4E | |
| SCHEMBL8976432 | 0.86 | LTB4R (0.44) | ALOX15MEN1KMT2ALTB4RLTB4R2 | |
| SCHEMBL9543338 | 0.79 | MEN1 (0.44) | MEN1KMT2ABACE1KDM4EPOLB | |
| SCHEMBL9543347 | 0.79 | MEN1 (0.44) | MEN1KMT2ABACE1KDM4EPOLB | |
| SCHEMBL1625900 | 0.78 | BACE1 (0.47) | MEN1KMT2ABACE1KDM4E | |
| SCHEMBL1625898 | 0.78 | BACE1 (0.47) | MEN1KMT2ABACE1KDM4E | |
| SCHEMBL5703818 | 0.77 | MEN1 (0.51) | MEN1KMT2ABACE1KDM4E | |
| SCHEMBL19245779 | 0.77 | TAAR1 (0.46) | MEN1KMT2ABACE1KDM4E | |
| SCHEMBL27635276 | 0.77 | GLI1 (0.46) | MEN1KMT2ABACE1KDM4E | |
| SCHEMBL19352857 | 0.76 | BACE1 (0.45) | BACE1ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5480910-A | 4-(2-(2-HYDROXY-2-PHENYLETHYLAMINO)ETHOXY)PHENYLACETIC ACID OR SALT IS ADMINISTERED FOR GASTROINTESTINAL DISORDERS | ZENECA LIMITED (GB) | 1996-01-02 | — | — | US | disclosed |
| EP-0516349-B1 | 2-Hydroxy-2-phenylethylamine derivatives as beta-3-adrenoceptor agonists | ZENECA LTD (GB) | 1995-09-20 | — | — | EP | disclosed |
| US-5393779-A | Anti-obesity, hypoglycemic, adrenergic blocking agents | ZENECA LIMITED (GB) | 1995-02-28 | — | — | US | disclosed |
| EP-0516349-A2 | 2-Hydroxy-2-phenylethylamine derivatives as beta-3-adrenoceptor agonists | ZENECA LIMITED (GB) | 1992-12-02 | — | — | EP | disclosed |