Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 7/20 | 0.58 |
| ▸ | RECQL | P46063 | 6/20 | 0.58 |
| ▸ | CTDSP1 | Q9GZU7 | 3/20 | 0.58 |
| ▸ | PTP4A3 | O75365 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 7/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.54 |
| ▸ | POLB | P06746 | 6/20 | 0.54 |
| ▸ | PKM | P14618 | 4/20 | 0.54 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | NSD2 | O96028 | 3/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.54 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.54 |
| ▸ | APBA1 | Q02410 | 2/20 | 0.54 |
| ▸ | BLM | P54132 | 2/20 | 0.54 |
| ▸ | USP2 | O75604 | 2/20 | 0.54 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.54 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.54 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16229922 | 0.89 | TDP1 (0.47) | TDP1RECQLCTDSP1PTP4A3MEN1 | |
| SCHEMBL16223222 | 0.85 | RECQL (0.57) | TDP1RECQLCTDSP1MEN1KMT2A | |
| SCHEMBL16245678 | 0.84 | POLB (0.45) | TDP1RECQLCTDSP1PTP4A3MEN1 | |
| SCHEMBL16223359 | 0.83 | MAPT (0.63) | TDP1RECQLMEN1KMT2APKM | |
| SCHEMBL16245623 | 0.83 | GAA (0.58) | TDP1RECQLCTDSP1PTP4A3MEN1 | |
| SCHEMBL16223157 | 0.82 | MEN1 (0.50) | TDP1RECQLCTDSP1PTP4A3MEN1 | |
| Hydrochloric Acid SCHEMBL16245570 | 0.82 | MAPT (0.61) | TDP1RECQLMEN1KMT2APKM | |
| SCHEMBL16223234 | 0.81 | MAPT (0.48) | TDP1RECQLMEN1KMT2APOLB | |
| SCHEMBL16223248 | 0.79 | CFTR (0.61) | MEN1KMT2APKMMAPTHTT | |
| SCHEMBL16223188 | 0.77 | MAPT (0.55) | TDP1MEN1KMT2APOLBPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2801573-A1 | Hydantoine derivatives as CD38 inhibitors | SANOFI (FR) | 2014-11-12 | — | — | EP | claimed |
| WO-2014180544-A1 | HYDANTOINE DERIVATIVES AS CD38 INHIBITORS | SANOFI (FR) | 2014-11-13 | — | — | WO | disclosed |
| WO-2014180544-A1 | HYDANTOINE DERIVATIVES AS CD38 INHIBITORS | SANOFI (FR) | 2014-11-13 | — | — | WO | disclosed |
| EP-2801573-A1 | Hydantoine derivatives as CD38 inhibitors | SANOFI (FR) | 2014-11-12 | — | — | EP | disclosed |
| EP-2801573-A1 | Hydantoine derivatives as CD38 inhibitors | SANOFI (FR) | 2014-11-12 | — | — | EP | disclosed |