Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 5/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.57 |
| ▸ | APEX1 | P27695 | 4/20 | 0.57 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.57 |
| ▸ | DNMT1 | P26358 | 3/20 | 0.57 |
| ▸ | NSD2 | O96028 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | MEN1 | O00255 | 5/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | PKM | P14618 | 3/20 | 0.48 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.48 |
| ▸ | APBA1 | Q02410 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | CA12 | O43570 | 2/20 | 0.47 |
| ▸ | CA9 | Q16790 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16229912 | 0.88 | MAPT (0.46) | RECQLTDP1APEX1MCL1DNMT1 | |
| SCHEMBL16223148 | 0.85 | TDP1 (0.58) | RECQLTDP1APEX1MCL1DNMT1 | |
| SCHEMBL16223359 | 0.85 | MAPT (0.63) | RECQLTDP1APEX1MCL1DNMT1 | |
| SCHEMBL16223317 | 0.84 | MCHR1 (0.47) | RECQLTDP1APEX1MCL1DNMT1 | |
| SCHEMBL16223191 | 0.84 | MCHR1 (0.47) | RECQLTDP1APEX1MCL1DNMT1 | |
| Hydrochloric Acid SCHEMBL16245570 | 0.83 | MAPT (0.61) | RECQLTDP1APEX1MCL1DNMT1 | |
| SCHEMBL16223221 | 0.83 | MEN1 (0.53) | RECQLTDP1APEX1MCL1DNMT1 | |
| SCHEMBL16223194 | 0.82 | MAPT (0.50) | RECQLTDP1MCL1DNMT1NSD2 | |
| SCHEMBL16245627 | 0.82 | MAPT (0.50) | MAPTMEN1KMT2AHTTALDH1A1 | |
| SCHEMBL16245908 | 0.82 | ITGA4 (0.52) | RECQLTDP1MCL1NSD2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014180544-A1 | HYDANTOINE DERIVATIVES AS CD38 INHIBITORS | SANOFI (FR) | 2014-11-13 | — | — | WO | claimed |
| EP-2801573-A1 | Hydantoine derivatives as CD38 inhibitors | SANOFI (FR) | 2014-11-12 | — | — | EP | claimed |
| EP-2801573-A1 | Hydantoine derivatives as CD38 inhibitors | SANOFI (FR) | 2014-11-12 | — | — | EP | disclosed |