Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | CASP1 | P29466 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | HBB | P68871 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4401093 | 0.77 | CYP2A6 (0.34) | ALDH1A1HSD17B10KDM4ETSHRHTT | |
| SCHEMBL4397412 | 0.77 | CYP1A2 (0.34) | — | |
| SCHEMBL2889003 | 0.77 | CYP1A2 (0.50) | ALDH1A1KDM4ETDP1 | |
| SCHEMBL4402445 | 0.77 | CYP2A6 (0.34) | HTTSMN1; SMN2 | |
| SCHEMBL3824244 | 0.74 | KDM4E (0.47) | ALDH1A1CASP1KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL10321126 | 0.73 | CYP1A2 (0.41) | ALDH1A1CYP3A4EGFR | |
| SCHEMBL4399735 | 0.72 | PDGFRB (0.56) | ALDH1A1HSD17B10CASP1KDM4EMAPT | |
| SCHEMBL4843211 | 0.71 | PDPK1 (0.36) | ALDH1A1KDM4EPDPK1 | |
| SCHEMBL4843376 | 0.69 | BACE1 (0.36) | ALDH1A1HSD17B10KDM4EMAPTPDPK1 | |
| SCHEMBL19695 | 0.69 | TSHR (0.42) | ALDH1A1HSD17B10CASP1KDM4ETP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2545052-B1 | IMIDAZOPYRIDINES SYK INHIBITORS | GILEAD CONNECTICUT INC (US) | 2014-11-12 | — | — | EP | claimed |