SCHEMBL19695

SCHEMBL19695

[c]1cccc2cccnc12

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.42
HTT P42858 3/20 0.42
LMNA P02545 3/20 0.42
KDM4E B2RXH2 3/20 0.42
MAPT P10636 3/20 0.42
MMP2 P08253 2/20 0.42
CYP3A4 P08684 2/20 0.42
TP53 P04637 2/20 0.42
HSP90AA1 P07900 2/20 0.42
SMN1; SMN2 Q16637 2/20 0.42
GMNN O75496 1/20 0.42
CYP2D6 P10635 1/20 0.42
MMP9 P14780 1/20 0.42
ALOX15 P16050 1/20 0.42
NFKB1 P19838 1/20 0.42
MMP8 P22894 1/20 0.42
CCR1 P32246 1/20 0.42
THPO P40225 1/20 0.42
MTOR P42345 1/20 0.42
MMP13 P45452 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27643304 0.98 TSHR (0.41) TSHRHTTLMNAKDM4EMAPT
SCHEMBL27643306 0.98 TSHR (0.41) TSHRHTTLMNAKDM4EMAPT
SCHEMBL27594643 0.98 TSHR (0.41) TSHRHTTLMNAKDM4EMAPT
SCHEMBL21831938 0.98 TSHR (0.41) TSHRHTTLMNAKDM4EMAPT
SCHEMBL27504674 0.98 TSHR (0.41) TSHRHTTLMNAKDM4EMAPT
SCHEMBL27380184 0.98 TSHR (0.41) TSHRHTTLMNAKDM4EMAPT
SCHEMBL28258823 0.81 ALDH1A1 (0.32) ALDH1A1
SCHEMBL17511921 0.73 LMNA (0.44) TSHRHTTLMNAKDM4EMAPT
SCHEMBL6904790 0.73 KDM4E (0.52) HTTLMNAKDM4EMAPTTP53
SCHEMBL19690 0.73

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 22579 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024145659-A1 HETEROCYCLE FUSED GAMMA-CARBOLINES ACTING ON THE SEROTONINE 5-HT2A RECEPTOR INTRA-CELLULAR THERAPIES, INC. (US) 2024-07-04 WO claimed
US-11993590-B2 Pyranone compounds useful to modulate OMA1 protease 712 NORTH INC. (US) 2024-05-28 US claimed
WO-2024105420-A2 CYCLIC DESIGNER SCAFFOLDS FOR THE COVALENT TARGETING OF PROTEINS VIA MICHAEL ADDITION Természettudományi Kutatóközpont (HU) 2024-05-23 WO claimed
US-11987588-B2 Modulators of the beta-3 adrenergic receptor useful for the treatment or prevention of heart failure and disorders related thereto ARENA PHARMACEUTICALS, INC. (US) 2024-05-21 US claimed
EP-4361141-A1 PROTEIN DEGRADATION AGENT Suzhou Kintor Pharmaceuticals, Inc. (CN) 2024-05-01 EP claimed
WO-2024086570-A1 POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M1 VANDERBILT UNIVERSITY (US) 2024-04-25 WO claimed
WO-2024086569-A1 POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M1 VANDERBILT UNIVERSITY (US) 2024-04-25 WO claimed
US-11952376-B2 Substituted amino acids as integrin inhibitors PLIANT THERAPEUTICS, INC. (US) 2024-04-09 US claimed
US-20240101538-A1 PROTEIN-PROTEIN INTERACTION MODULATORS OF AURORA KINASE A AND THEIR USE IN THE PREVENTION AND/OR TREATMENT OF CANCER EBERHARD KARLS UNIVERSITÄT TÜBINGEN (DE) 2024-03-28 US claimed
EP-3532474-B1 4,5-ANNULATED 1,2,4-TRIAZOLONES BAYER AG (DE) 2024-03-27 EP claimed
US-4267316-A HETEROCYCLIC ESTERS OF PSEUDOMONIC ACID; UROGENITAL DISORDERS; NEISSERIA; BRONCHIUS; VETERINARY MEDICINE BEECHAM GROUP LIMITED (GB) 1981-05-12 US claimed
US-4245064-A Activated solid carrier and a method of its preparation CESKOSLOVENSKA AKADEMIE VED (CS) 1981-01-13 US claimed
EP-0008746-A1 Alpha-(N-arylsulfonyl-L-argininamides, processes for their preparation and pharmaceutical compositions containing these substances MITSUBISHI KASEI CORPORATION (JP) 1980-03-19 EP claimed
US-4167638-A Process for production of 8-NHR quinolines THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) 1979-09-11 US claimed
US-4132436-A Recording material FUJI PHOTO FILM CO., LTD. (JP) 1979-01-02 US claimed
US-4119777-A BY OXIDATION OF A THIOAMIDE DERIVATIVE FUJI PHOTO FILM CO., LTD. (JP) 1978-10-10 US claimed
US-4118561-A ANTIBACTERIAL, SYNERGISTIC, ANTI-CANCER ACTIVITY, ANTI-FOLIC ACID ACTIVITY AMERICAN HOME PRODUCTS CORPORATION (US) 1978-10-03 US claimed
US-4013631-A SYNTHETIC FIBERS BAYER AKTIENGESELLSCHAFT (DT) 1977-03-22 US claimed
US-3987172-A HYPOGLYCEMIC AGENTS PFIZER INC. (US) 1976-10-19 US claimed
US-3971784-A ANTIMETABOLITES MITSUI PHARMACEUTICALS, INCORPORATED (JA) 1976-07-27 US claimed