Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | CTSB | P07858 | 1/20 | 0.46 |
| ▸ | TLR9 | Q9NR96 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.40 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31401808 | 0.85 | TSHR (0.56) | ALDH1A1TDP1CYP3A4ALOX15HSD17B10 | |
| SCHEMBL4442634 | 0.85 | TSHR (0.56) | ALDH1A1TDP1CYP3A4ALOX15HSD17B10 | |
| SCHEMBL8108179 | 0.83 | TDP1 (0.64) | ALDH1A1TDP1MEN1KMT2AGAA | |
| SCHEMBL26656853 | 0.83 | CTSB (0.58) | ALDH1A1TDP1HSD17B10MEN1KMT2A | |
| SCHEMBL14577245 | 0.80 | BCHE (0.47) | ALDH1A1TDP1CYP3A4ALOX15GAA | |
| SCHEMBL12920010 | 0.78 | TSHR (0.51) | ALDH1A1TDP1CYP3A4MEN1KMT2A | |
| SCHEMBL3894592 | 0.77 | TSHR (0.48) | ALDH1A1TDP1CYP3A4ALOX15HSD17B10 | |
| SCHEMBL11808349 | 0.77 | TDP1 (0.55) | ALDH1A1TDP1CYP3A4ALOX15HSD17B10 | |
| SCHEMBL28408395 | 0.74 | ALDH1A1 (0.63) | ALDH1A1TDP1CYP3A4HSD17B10GAA | |
| SCHEMBL334763 | 0.74 | ALDH1A1 (0.63) | ALDH1A1TDP1CYP3A4HSD17B10GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014179567-A2 | METHODS AND COMPOSITIONS FOR TREATING BETA-THALASSEMIA AND SICKLE CELL DISEASE | ACADEMIA SINICA (TW) | 2014-11-06 | — | — | WO | disclosed |