Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.72 |
| ▸ | MTOR | P42345 | 2/20 | 0.72 |
| ▸ | THRB | P10828 | 1/20 | 0.72 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.72 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.72 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.72 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | CDA | P32320 | 1/20 | 0.61 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.60 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.60 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.60 |
| ▸ | SLC28A3 | Q9HAS3 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | GMNN | O75496 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.57 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.57 |
| ▸ | THPO | P40225 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18503539 | 1.00 | LMNA (0.72) | LMNAMTORTHRBMDM2NCOA1 | |
| SCHEMBL13026809 | 1.00 | LMNA (0.72) | LMNAMTORTHRBMDM2NCOA1 | |
| SCHEMBL18512923 | 1.00 | LMNA (0.72) | LMNAMTORTHRBMDM2NCOA1 | |
| SCHEMBL18720728 | 1.00 | LMNA (0.72) | LMNAMTORTHRBMDM2NCOA1 | |
| SCHEMBL16311919 | 0.90 | LMNA (0.58) | LMNAMTORTHRBMDM2NCOA1 | |
| SCHEMBL14418619 | 0.89 | LMNA (0.57) | LMNAMTORTHRBMDM2NCOA1 | |
| SCHEMBL16556358 | 0.88 | LMNA (0.57) | LMNAMTORTHRBMDM2NCOA1 | |
| SCHEMBL25834222 | 0.88 | LMNA (0.56) | LMNAMTORTHRBMDM2NCOA1 | |
| SCHEMBL18503527 | 0.87 | LMNA (0.56) | LMNAMTORTHRBMDM2NCOA1 | |
| SCHEMBL18512849 | 0.86 | LMNA (0.55) | LMNAMTORTHRBMDM2NCOA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8884001-B2 | Preparation of intermediates useful in the synthesis of 2′-cyano-2′-deoxy-N4-palmi-toyl-1-β-D-arabinofuranosylcytosine | CYCLACEL LIMITED (GB) | 2014-11-11 | — | — | US | disclosed |