Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 15/20 | 0.80 |
| ▸ | SIRT1 | Q96EB6 | 12/20 | 0.80 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.51 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.51 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16229470 | 0.91 | SIRT2 (0.85) | SIRT2SIRT1 | |
| SCHEMBL16229460 | 0.91 | SIRT2 (0.82) | SIRT2SIRT1 | |
| SCHEMBL16229475 | 0.88 | SIRT2 (0.63) | SIRT2SIRT1CYP2C9ALOX12 | |
| Hydrochloric Acid SCHEMBL1706966 | 0.88 | SIRT2 (0.98) | SIRT2SIRT1 | |
| SCHEMBL16229459 | 0.88 | SIRT2 (0.63) | SIRT2SIRT1 | |
| SCHEMBL16229454 | 0.86 | SIRT2 (0.78) | SIRT2SIRT1 | |
| SCHEMBL16229472 | 0.85 | SIRT2 (0.63) | SIRT2SIRT1 | |
| Hydrochloric Acid SCHEMBL1706649 | 0.83 | SIRT2 (0.98) | SIRT2SIRT1 | |
| SCHEMBL16229381 | 0.82 | SIRT1 (0.67) | SIRT2SIRT1 | |
| SCHEMBL16229457 | 0.81 | ALDH1A1 (0.65) | SIRT2SIRT1ALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440522-B1 | AROYLTHIOUREA AND ARYLTHIOCARBONYLUREA DERIVATIVES | UNIV DUNDEE (GB) | 2014-11-12 | — | — | EP | disclosed |