Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 15/20 | 0.82 |
| ▸ | SIRT1 | Q96EB6 | 15/20 | 0.82 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16229389 | 0.95 | SIRT2 (0.86) | SIRT2SIRT1SIRT3POLBTDP1 | |
| SCHEMBL16229469 | 0.92 | SIRT2 (0.73) | SIRT2SIRT1SIRT3TDP1KDM4E | |
| Hydrochloric Acid SCHEMBL1708338 | 0.89 | SIRT2 (1.00) | SIRT2SIRT1SIRT3 | |
| SCHEMBL16229386 | 0.88 | MEN1 (0.70) | SIRT2SIRT1SIRT3KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL1706964 | 0.87 | SIRT2 (1.00) | SIRT2SIRT1SIRT3 | |
| SCHEMBL16229471 | 0.87 | SIRT2 (1.00) | SIRT2SIRT1SIRT3 | |
| SCHEMBL16229381 | 0.87 | SIRT1 (0.67) | SIRT2SIRT1SIRT3ALDH1A1 | |
| SCHEMBL16229383 | 0.87 | SIRT2 (0.77) | SIRT2SIRT1SIRT3ALDH1A1 | |
| SCHEMBL16229390 | 0.86 | ALDH1A1 (0.70) | SIRT2SIRT1POLBALDH1A1 | |
| Hydrochloric Acid SCHEMBL1707578 | 0.86 | SIRT2 (1.00) | SIRT2SIRT1SIRT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440522-B1 | AROYLTHIOUREA AND ARYLTHIOCARBONYLUREA DERIVATIVES | UNIV DUNDEE (GB) | 2014-11-12 | — | — | EP | disclosed |