Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 17/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.57 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16784626 | 0.91 | SLC6A9 (0.50) | SLC6A9KCNH2MAOB | |
| SCHEMBL16784655 | 0.91 | SLC6A9 (0.50) | SLC6A9KCNH2 | |
| SCHEMBL16229781 | 0.89 | SLC6A9 (0.49) | SLC6A9KCNH2SLC6A4 | |
| SCHEMBL16229747 | 0.87 | SLC6A9 (0.43) | SLC6A9KCNH2 | |
| SCHEMBL16229750 | 0.86 | SLC6A9 (0.46) | SLC6A9KCNH2MAOB | |
| SCHEMBL16784624 | 0.86 | SLC6A9 (0.46) | SLC6A9KCNH2 | |
| SCHEMBL16784628 | 0.85 | SLC6A9 (0.44) | SLC6A9KCNH2 | |
| SCHEMBL16229752 | 0.82 | SLC6A9 (0.52) | SLC6A9KCNH2 | |
| SCHEMBL16229774 | 0.82 | SLC6A9 (0.65) | SLC6A9KCNH2 | |
| SCHEMBL16229782 | 0.80 | SLC6A9 (0.39) | SLC6A9KCNH2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9051280-B2 | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy | AbbVie Deutschland GmbH & Co. KG (DE) | 2015-06-09 | — | — | US | disclosed |
| US-8883839-B2 | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy | ABBOTT LABORATORIES (US) | 2014-11-11 | — | — | US | disclosed |