Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 14/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | HTR1A | P08908 | 3/20 | 0.40 |
| ▸ | HTR7 | P34969 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SLC8A1 | P32418 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16784630 | 0.92 | SLC6A9 (0.54) | SLC6A9KCNH2HTR1AHTR7 | |
| SCHEMBL16784653 | 0.92 | SLC6A9 (0.51) | SLC6A9KCNH2HTR1AHTR7SLC8A1 | |
| SCHEMBL16784632 | 0.90 | SLC6A9 (0.52) | SLC6A9KCNH2HTR1AHTR7ALDH1A1 | |
| SCHEMBL16784640 | 0.88 | SLC6A9 (0.41) | SLC6A9KCNH2HTR1AHTR7ALDH1A1 | |
| SCHEMBL16229746 | 0.87 | HTT (0.40) | SLC6A9ALDH1A1SLC8A1HTT | |
| SCHEMBL16229774 | 0.86 | SLC6A9 (0.65) | SLC6A9KCNH2SLC8A1MEN1KMT2A | |
| SCHEMBL16784645 | 0.85 | SLC6A9 (0.41) | SLC6A9HTR1AHTR7ALDH1A1SLC8A1 | |
| SCHEMBL16229750 | 0.82 | SLC6A9 (0.46) | SLC6A9KCNH2 | |
| SCHEMBL16229745 | 0.82 | SLC6A9 (0.60) | SLC6A9KCNH2 | |
| SCHEMBL13738310 | 0.81 | SLC6A9 (0.55) | SLC6A9KCNH2HTR1AHTR7ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9051280-B2 | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy | AbbVie Deutschland GmbH & Co. KG (DE) | 2015-06-09 | — | — | US | disclosed |
| US-8883839-B2 | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy | ABBOTT LABORATORIES (US) | 2014-11-11 | — | — | US | disclosed |