Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 11/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | GALR3 | O60755 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16229797 | 0.93 | SLC6A9 (0.53) | SLC6A9KMT2AGAAMEN1LMNA | |
| SCHEMBL16229801 | 0.90 | SLC6A9 (0.51) | SLC6A9KMT2AGAAMEN1LMNA | |
| SCHEMBL16229803 | 0.89 | SLC6A9 (0.48) | SLC6A9KMT2AGAAMEN1LMNA | |
| SCHEMBL16229751 | 0.89 | SLC6A9 (0.60) | SLC6A9KMT2AGAAMEN1LMNA | |
| SCHEMBL16229796 | 0.88 | SLC6A9 (0.51) | SLC6A9KMT2AGAAMEN1LMNA | |
| SCHEMBL16229793 | 0.88 | SLC6A9 (0.68) | SLC6A9KMT2AGAAMEN1LMNA | |
| SCHEMBL16784636 | 0.85 | GALR3 (0.41) | SLC6A9LMNAGALR3ALDH1A1TRPV4 | |
| SCHEMBL16229811 | 0.85 | SLC6A9 (0.50) | SLC6A9KMT2AGAAMEN1LMNA | |
| SCHEMBL16229791 | 0.84 | SLC6A9 (0.55) | SLC6A9KMT2AGAAMEN1LMNA | |
| SCHEMBL16784644 | 0.83 | GALR3 (0.47) | SLC6A9GALR3ALDH1A1TRPV4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9051280-B2 | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy | AbbVie Deutschland GmbH & Co. KG (DE) | 2015-06-09 | — | — | US | disclosed |
| US-8883839-B2 | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy | ABBOTT LABORATORIES (US) | 2014-11-11 | — | — | US | disclosed |