Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GALR3 | O60755 | 1/20 | 0.47 |
| ▸ | TRPV4 | Q9HBA0 | 3/20 | 0.37 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.36 |
| ▸ | PRMT6 | Q96LA8 | 2/20 | 0.36 |
| ▸ | SLC6A9 | P48067 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | GUSB | P08236 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | AXL | P30530 | 1/20 | 0.34 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.34 |
| ▸ | MERTK | Q12866 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16229808 | 0.94 | GALR3 (0.42) | GALR3TRPV4CARM1PRMT6SLC6A9 | |
| SCHEMBL16784642 | 0.89 | SLC6A9 (0.35) | GALR3CARM1PRMT6SLC6A9GUSB | |
| SCHEMBL16784643 | 0.89 | GALR3 (0.43) | GALR3TRPV4CARM1PRMT6SLC6A9 | |
| SCHEMBL16784628 | 0.88 | SLC6A9 (0.44) | GALR3SLC6A9ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL16784637 | 0.88 | GALR3 (0.43) | GALR3TRPV4CARM1PRMT6SLC6A9 | |
| SCHEMBL16784656 | 0.87 | SLC6A9 (0.35) | GALR3CARM1PRMT6SLC6A9HSD11B1 | |
| SCHEMBL16229781 | 0.87 | SLC6A9 (0.49) | GALR3SLC6A9 | |
| SCHEMBL16229802 | 0.84 | GALR3 (0.38) | GALR3TRPV4CARM1PRMT6SLC6A9 | |
| SCHEMBL16784636 | 0.83 | GALR3 (0.41) | GALR3TRPV4CARM1PRMT6SLC6A9 | |
| SCHEMBL16229771 | 0.83 | GALR3 (0.38) | GALR3CARM1PRMT6SLC6A9KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9051280-B2 | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy | AbbVie Deutschland GmbH & Co. KG (DE) | 2015-06-09 | — | — | US | disclosed |