Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | SLC6A9 | P48067 | 12/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.37 |
| ▸ | MGAT3 | Q09327 | 1/20 | 0.37 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16229801 | 0.92 | SLC6A9 (0.51) | KMT2ASLC6A9GAAMEN1KCNH2 | |
| SCHEMBL16229779 | 0.91 | KMT2A (0.51) | KMT2ASLC6A9GAAMEN1KCNH2 | |
| SCHEMBL16229780 | 0.91 | SLC6A9 (0.52) | KMT2ASLC6A9GAAMEN1KCNH2 | |
| SCHEMBL16229797 | 0.90 | SLC6A9 (0.53) | KMT2ASLC6A9GAAMEN1KCNH2 | |
| SCHEMBL16229788 | 0.89 | KMT2A (0.41) | KMT2ASLC6A9GAAMEN1KCNH2 | |
| SCHEMBL16229749 | 0.89 | SLC6A9 (0.55) | KMT2ASLC6A9GAAMEN1KCNH2 | |
| SCHEMBL16229789 | 0.85 | DGAT1 (0.40) | KMT2ASLC6A9LMNADGAT1MGAT3 | |
| SCHEMBL16229773 | 0.85 | SLC6A9 (0.45) | KMT2ASLC6A9GAAMEN1KCNH2 | |
| SCHEMBL16229760 | 0.85 | KMT2A (0.45) | KMT2ASLC6A9GAAMEN1KCNH2 | |
| SCHEMBL16229751 | 0.83 | SLC6A9 (0.60) | KMT2ASLC6A9GAAMEN1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9051280-B2 | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy | AbbVie Deutschland GmbH & Co. KG (DE) | 2015-06-09 | — | — | US | disclosed |
| US-8883839-B2 | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy | ABBOTT LABORATORIES (US) | 2014-11-11 | — | — | US | disclosed |