Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 12/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | GALR3 | O60755 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16784639 | 0.90 | SLC6A9 (0.45) | SLC6A9KCNH2HTR1AHTR7 | |
| SCHEMBL16229750 | 0.89 | SLC6A9 (0.46) | SLC6A9KCNH2 | |
| SCHEMBL16229812 | 0.89 | SLC6A9 (0.39) | SLC6A9GALR3ACHE | |
| SCHEMBL16784646 | 0.89 | SLC6A9 (0.49) | SLC6A9KCNH2 | |
| SCHEMBL16229781 | 0.88 | SLC6A9 (0.49) | SLC6A9KCNH2HRH3SLC6A4GALR3 | |
| SCHEMBL16229771 | 0.88 | GALR3 (0.38) | SLC6A9KCNH2GALR3 | |
| SCHEMBL16784637 | 0.86 | GALR3 (0.43) | SLC6A9HRH3GALR3 | |
| SCHEMBL16229793 | 0.84 | SLC6A9 (0.68) | SLC6A9KCNH2 | |
| SCHEMBL16784632 | 0.84 | SLC6A9 (0.52) | SLC6A9KCNH2HTR1AHTR7 | |
| SCHEMBL16229795 | 0.83 | GALR3 (0.35) | SLC6A9GALR3ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9051280-B2 | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy | AbbVie Deutschland GmbH & Co. KG (DE) | 2015-06-09 | — | — | US | disclosed |
| US-8883839-B2 | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy | ABBOTT LABORATORIES (US) | 2014-11-11 | — | — | US | disclosed |