Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GALR3 | O60755 | 1/20 | 0.35 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.33 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.33 |
| ▸ | CARM1 | Q86X55 | 3/20 | 0.32 |
| ▸ | PRMT6 | Q96LA8 | 3/20 | 0.32 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | AXL | P30530 | 1/20 | 0.30 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.30 |
| ▸ | MERTK | Q12866 | 1/20 | 0.30 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16784647 | 0.92 | GALR3 (0.38) | GALR3SLC6A9CARM1PRMT6PLA2G1B | |
| SCHEMBL16229754 | 0.91 | RORC (0.32) | NR1D1 | |
| SCHEMBL16229778 | 0.90 | NR1D1 (0.33) | NR1D1PKM | |
| SCHEMBL16229769 | 0.89 | DPP4 (0.34) | SLC6A9PKMDPP4NPC1 | |
| SCHEMBL16229771 | 0.88 | GALR3 (0.38) | GALR3SLC6A9CARM1PRMT6DPP4 | |
| SCHEMBL16229812 | 0.88 | SLC6A9 (0.39) | GALR3SLC6A9CARM1PRMT6PLA2G1B | |
| SCHEMBL16229802 | 0.88 | GALR3 (0.38) | GALR3SLC6A9CARM1PRMT6DPP4 | |
| SCHEMBL16229800 | 0.84 | SLC6A9 (0.36) | GALR3SLC6A9NPC1RAB9AAXL | |
| SCHEMBL16784637 | 0.83 | GALR3 (0.43) | GALR3SLC6A9CARM1PRMT6PLA2G1B | |
| SCHEMBL16229811 | 0.83 | SLC6A9 (0.50) | SLC6A9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9051280-B2 | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy | AbbVie Deutschland GmbH & Co. KG (DE) | 2015-06-09 | — | — | US | disclosed |
| US-8883839-B2 | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy | ABBOTT LABORATORIES (US) | 2014-11-11 | — | — | US | disclosed |