Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.37 |
| ▸ | ALB | P02768 | 3/20 | 0.36 |
| ▸ | GNPAT | O15228 | 1/20 | 0.36 |
| ▸ | CASP2 | P42575 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.34 |
| ▸ | NAAA | Q02083 | 1/20 | 0.34 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21913856 | 0.90 | ALDH1A1 (0.43) | FOLH1ALDH1A1ALBCASP2TSHR | |
| SCHEMBL16409459 | 0.87 | CASP2 (0.51) | ALDH1A1ALBCASP2NAAANOD1 | |
| SCHEMBL14952664 | 0.87 | ALDH1A1 (0.41) | FOLH1ALDH1A1ALBCASP2LMNA | |
| SCHEMBL25129545 | 0.86 | ALDH1A1 (0.37) | FOLH1ALDH1A1ALBCASP2LMNA | |
| SCHEMBL16248536 | 0.86 | NAMPT (0.40) | ALDH1A1ALBCASP2LMNATSHR | |
| SCHEMBL20729996 | 0.86 | ALB (0.38) | FOLH1ALDH1A1SIRT5ALBCASP2 | |
| SCHEMBL23944184 | 0.86 | ALDH1A1 (0.40) | FOLH1ALDH1A1ALBCASP2NAAA | |
| SCHEMBL25132500 | 0.84 | ALB (0.37) | FOLH1ALDH1A1EPHX2ALBCASP2 | |
| SCHEMBL25132903 | 0.84 | ALB (0.37) | FOLH1ALDH1A1EPHX2ALBCASP2 | |
| SCHEMBL25132901 | 0.84 | ALB (0.37) | FOLH1ALDH1A1EPHX2ALBCASP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180155760-A1 | FLUORESCENT SUBSTRATES FOR DETERMINING LYSINE MODIFYING ENZYME ACTIVITY | BROAD INST INC (US) | 2018-06-07 | — | — | US | disclosed |
| US-9856509-B2 | Fluorescent substrates for determining lysine modifying enzyme activity | THE BROAD INSTITUTE, INC. (US) | 2018-01-02 | — | — | US | disclosed |
| US-20140335550-A1 | FLUORESCENT SUBSTRATES FOR DETERMINING LYSINE MODIFYING ENZYME ACTIVITY | THE BROAD INSTITUTE, INC. (US) | 2014-11-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180155760-A1 | FLUORESCENT SUBSTRATES FOR DETERMINING LYSINE MODIFYING ENZYME ACTIVITY | KDM1A, MAN2B1, KDM3A | FOLH1 814/4885ALDH1A1 261/4885SIRT5 879/4885 |
| US-20140335550-A1 | FLUORESCENT SUBSTRATES FOR DETERMINING LYSINE MODIFYING ENZYME ACTIVITY | MAN2B1, KDM1A, KDM3A | FOLH1 525/4885ALDH1A1 217/4885SIRT5 1132/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.