Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 2/20 | 0.38 |
| ▸ | DAO | P14920 | 5/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16232036 | 0.88 | THRA (0.36) | THRATHRBDAOKMT2AKDM4E | |
| SCHEMBL16231868 | 0.85 | DAO (0.35) | DAOKDM4EPKMALDH1A1MAPT | |
| SCHEMBL16234175 | 0.82 | TIPARP (0.34) | THRATHRBDAOPOLBKMT2A | |
| SCHEMBL16232037 | 0.82 | DAO (0.36) | DAOPOLBKMT2AKDM4EALDH1A1 | |
| SCHEMBL16231990 | 0.81 | DAO (0.41) | DAO | |
| SCHEMBL16231919 | 0.80 | AR (0.44) | THRATHRBDAOPOLBKMT2A | |
| SCHEMBL16231922 | 0.80 | SLC5A2 (0.36) | DAOPOLBKMT2AKDM4EALDH1A1 | |
| SCHEMBL16231917 | 0.78 | AR (0.43) | DAOMAPT | |
| SCHEMBL16232004 | 0.77 | KDM4E (0.31) | DAOKDM4EPKM | |
| SCHEMBL16228499 | 0.77 | DAO (0.57) | DAOMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170107226-A1 | DIHYDROXY AROMATIC HETEROCYCLIC COMPOUND | ASTELLAS PHARMA INC. (JP) | 2017-04-20 | — | — | US | disclosed |
| US-9562020-B2 | Dihydroxy aromatic heterocyclic compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2017-02-07 | — | — | US | disclosed |
| US-20160039771-A1 | DIHYDROXY AROMATIC HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL (JP) | 2016-02-11 | — | — | US | disclosed |
| US-9212147-B2 | Dihydroxy aromatic heterocyclic compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2015-12-15 | — | — | US | disclosed |
| US-20140336165-A1 | DIHYDROXY AROMATIC HETEROCYCLIC COMPOUND | ASTELLAS PHARMA INC. (JP) | 2014-11-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160039771-A1 | DIHYDROXY AROMATIC HETEROCYCLIC COMPOUND | DAO, DDO, DDC | THRA 3191/4885THRB 3534/4885DAO 1/4885 |
| US-20140336165-A1 | DIHYDROXY AROMATIC HETEROCYCLIC COMPOUND | DAO, DDO, DDC | THRA 3157/4885THRB 3503/4885DAO 1/4885 |
| US-20170107226-A1 | DIHYDROXY AROMATIC HETEROCYCLIC COMPOUND | DAO, DDO, DDC | THRA 3157/4885THRB 3503/4885DAO 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.