Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 6/20 | 0.56 |
| ▸ | CCR1 | P32246 | 6/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | FLT1 | P17948 | 1/20 | 0.46 |
| ▸ | FLT4 | P35916 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16234828 | 0.88 | CCR1 (0.60) | TRPA1CCR1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL16235034 | 0.84 | CCR1 (0.60) | TRPA1CCR1POLBKDM4EALDH1A1 | |
| SCHEMBL16234990 | 0.84 | CCR1 (0.60) | TRPA1CCR1POLBKDM4EALDH1A1 | |
| SCHEMBL16235094 | 0.84 | TRPA1 (0.66) | TRPA1CCR1POLBP2RX7ALDH1A1 | |
| SCHEMBL16235037 | 0.83 | POLB (0.47) | POLBP2RX7KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL16235119 | 0.83 | TRPA1 (0.65) | TRPA1CCR1POLBP2RX7KCNH2 | |
| SCHEMBL9464737 | 0.81 | POLB (0.53) | CCR1POLBP2RX7KDM4EALDH1A1 | |
| SCHEMBL9464741 | 0.81 | POLB (0.53) | CCR1POLBP2RX7KDM4EALDH1A1 | |
| SCHEMBL16235058 | 0.77 | NPC1 (0.57) | TRPA1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL16234895 | 0.76 | TRPA1 (0.80) | TRPA1KDM4EALDH1A1FLT1FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014184235-A1 | BENZAMIDE TRPA1 ANTAGONISTS | Acturum Life Science AB (SE) | 2014-11-20 | — | — | WO | claimed |
| WO-2014184235-A1 | BENZAMIDE TRPA1 ANTAGONISTS | Acturum Life Science AB (SE) | 2014-11-20 | — | — | WO | disclosed |