Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATF1 | P18846 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | CCR4 | P51679 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.34 |
| ▸ | PDE4A | P27815 | 2/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.34 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.34 |
| ▸ | PDE11A | Q9HCR9 | 2/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | ALPL | P05186 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.31 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.30 |
| ▸ | EDNRB | P24530 | 1/20 | 0.30 |
| ▸ | EDNRA | P25101 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16235728 | 0.83 | ATF1 (0.39) | ATF1NFKB1HTTLMNAL3MBTL1 | |
| SCHEMBL16235389 | 0.73 | HTT (0.30) | CCR4SCN9ASCN5AHTT | |
| SCHEMBL16235234 | 0.71 | FLT1 (0.38) | HTTL3MBTL1MEN1KMT2AKDM4E | |
| SCHEMBL16234950 | 0.70 | HTT (0.33) | CCR4HTT | |
| SCHEMBL16235456 | 0.69 | S100A9 (0.50) | CCR4PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL16235303 | 0.69 | HTT (0.32) | HTT | |
| SCHEMBL16235769 | 0.69 | COMT (0.35) | HTTLMNAL3MBTL1MEN1KMT2A | |
| SCHEMBL5736940 | 0.68 | PDE4B (0.41) | PDE4BPDE4APDE4CPDE4DPDE3B | |
| SCHEMBL16235182 | 0.68 | AR (0.34) | HTTLMNAL3MBTL1HPGD | |
| SCHEMBL16235299 | 0.66 | CCR4 (0.47) | CCR4SCN9AHTTEDNRBEDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2925743-A1 | N-(HETEROARYL)-SULFONAMIDE DERIVATIVES USEFUL AS S100-INHIBITORS | Active Biotech AB (SE) | 2015-10-07 | — | — | EP | disclosed |
| WO-2014184234-A1 | N-(HETEROARYL)-SULFONAMIDE DERIVATIVES USEFUL AS S100-INHIBITORS | ACTIVE BIOTECH AB (SE) | 2014-11-20 | — | — | WO | disclosed |