Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CPN1 | P15169 | 2/20 | 0.41 |
| ▸ | CPB2 | Q96IY4 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | SLC6A1 | P30531 | 4/20 | 0.38 |
| ▸ | SLC6A11 | P48066 | 3/20 | 0.38 |
| ▸ | SLC6A13 | Q9NSD5 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.37 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.37 |
| ▸ | SLC6A12 | P48065 | 2/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.37 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.34 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29244744 | 0.97 | CPN1 (0.43) | CPN1CPB2KMT2ASLC6A1SLC6A11 | |
| SCHEMBL1062304 | 0.97 | CPN1 (0.43) | CPN1CPB2KMT2ASLC6A1SLC6A11 | |
| SCHEMBL222367 | 0.88 | SLC6A1 (0.49) | CPN1CPB2SLC6A1SLC6A11SLC6A13 | |
| SCHEMBL3613801 | 0.88 | SLC6A1 (0.49) | CPN1CPB2SLC6A1SLC6A11SLC6A13 | |
| SCHEMBL222368 | 0.88 | SLC6A1 (0.49) | CPN1CPB2SLC6A1SLC6A11SLC6A13 | |
| SCHEMBL1222696 | 0.81 | SLC6A2 (0.36) | KMT2ASLC6A1SLC6A11SLC6A13GABRA5 | |
| SCHEMBL16527855 | 0.80 | CPN1 (0.46) | CPN1CPB2KMT2ASLC6A1SLC6A11 | |
| SCHEMBL1971612 | 0.80 | CPN1 (0.46) | CPN1CPB2KMT2ASLC6A1SLC6A11 | |
| SCHEMBL16528138 | 0.80 | CPN1 (0.46) | CPN1CPB2KMT2ASLC6A1SLC6A11 | |
| Hydrochloric Acid SCHEMBL25406552 | 0.79 | SLC6A2 (0.35) | SLC6A1SLC6A11SLC6A13GABRA5GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8283354-B2 | Voltage gated sodium and calcium channel inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-10-09 | — | — | US | disclosed |
| US-7928107-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-04-19 | — | — | US | disclosed |
| US-20060173018-A1 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED | 2006-08-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060173018-A1 | Quinazolines useful as modulators of ion channels | KCNQ1, KCNQ2, KCNN3 | CPN1 4259/4885CPB2 4607/4885KMT2A 2404/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.