Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 5/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.35 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.34 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.34 |
| ▸ | L3MBTL3 | Q96JM7 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.33 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.32 |
| ▸ | CDK4 | P11802 | 1/20 | 0.32 |
| ▸ | CCND1 | P24385 | 1/20 | 0.32 |
| ▸ | CCND3 | P30281 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8512587 | 0.99 | HSD11B1 (0.45) | HSD11B1ADRA1ARORCOPRL1OPRM1 | |
| SCHEMBL8511579 | 0.80 | HSD11B1 (0.72) | HSD11B1ADRA1ARORC | |
| SCHEMBL1159359 | 0.78 | MKNK1 (0.39) | HSD11B1OPRL1OPRM1MKNK1MKNK2 | |
| SCHEMBL974412 | 0.77 | HSD11B1 (0.51) | HSD11B1MKNK1MKNK2 | |
| SCHEMBL1160741 | 0.74 | HSD11B1 (0.46) | HSD11B1MKNK1MKNK2PTPN11PIM1 | |
| SCHEMBL974634 | 0.73 | KDM4E (0.47) | HSD11B1MKNK1MKNK2PTPN11MAPT | |
| SCHEMBL8509465 | 0.73 | PTPN11 (0.42) | HSD11B1OPRL1OPRM1MKNK1MKNK2 | |
| SCHEMBL8511584 | 0.73 | HSD11B1 (0.41) | HSD11B1MKNK1MKNK2PTPN11PIM1 | |
| SCHEMBL8509241 | 0.72 | PTPN11 (0.41) | HSD11B1OPRL1OPRM1MKNK1MKNK2 | |
| SCHEMBL8511069 | 0.72 | HSD11B1 (0.43) | HSD11B1PTPN11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2459549-B1 | TETRAHYDROQUINOXALINE UREA DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI SA (FR) | 2014-11-19 | — | — | EP | disclosed |