Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 9/20 | 0.46 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.44 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.35 |
| ▸ | CCND1 | P24385 | 1/20 | 0.35 |
| ▸ | CCND3 | P30281 | 1/20 | 0.35 |
| ▸ | CDK7 | P50613 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | CCNH | P51946 | 1/20 | 0.35 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.35 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.35 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1159359 | 0.81 | MKNK1 (0.39) | HSD11B1PTPN11MKNK1MKNK2PIM1 | |
| SCHEMBL974634 | 0.81 | KDM4E (0.47) | HSD11B1PTPN11MKNK1MKNK2MAPT | |
| SCHEMBL972838 | 0.81 | PTPN11 (0.39) | HSD11B1PTPN11MKNK1MKNK2PIM1 | |
| SCHEMBL8512541 | 0.80 | PTPN11 (0.35) | HSD11B1HSD11B2PTPN11MKNK1MKNK2 | |
| SCHEMBL975549 | 0.80 | MKNK1 (0.37) | HSD11B1HSD11B2PTPN11MKNK1MKNK2 | |
| SCHEMBL1160146 | 0.79 | PTPN11 (0.37) | HSD11B1PTPN11MKNK1MKNK2PIM1 | |
| SCHEMBL974017 | 0.79 | SMO (0.38) | HSD11B1PTPN11MKNK1MKNK2CCNT1 | |
| SCHEMBL8509465 | 0.79 | PTPN11 (0.42) | HSD11B1HSD11B2PTPN11MKNK1MKNK2 | |
| SCHEMBL974412 | 0.78 | HSD11B1 (0.51) | HSD11B1MKNK1MKNK2 | |
| SCHEMBL8509241 | 0.78 | PTPN11 (0.41) | HSD11B1PTPN11MKNK1MKNK2PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2714624-B1 | PROCESS FOR THE PREPARATION OF DEUTERATED COMPOUNDS CONTAINING N-ALKYL GROUPS | SANOFI SA (FR) | 2017-12-27 | — | — | EP | disclosed |
| EP-2714624-B1 | PROCESS FOR THE PREPARATION OF DEUTERATED COMPOUNDS CONTAINING N-ALKYL GROUPS | SANOFI SA (FR) | 2017-12-27 | — | — | EP | disclosed |
| US-9340489-B2 | Process for the preparation of deuterated compounds containing N-alkyl groups | SANOFI (FR) | 2016-05-17 | — | — | US | disclosed |
| US-9340489-B2 | Process for the preparation of deuterated compounds containing N-alkyl groups | SANOFI (FR) | 2016-05-17 | — | — | US | disclosed |
| US-9340489-B2 | Process for the preparation of deuterated compounds containing N-alkyl groups | SANOFI (FR) | 2016-05-17 | — | — | US | disclosed |
| EP-2459548-B1 | TETRAHYDROQUINOXALINE UREA DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI SA (FR) | 2014-11-19 | — | — | EP | disclosed |
| US-20140081019-A1 | PROCESS FOR THE PREPARATION OF DEUTERATED COMPOUNDS CONTAINING N-ALKYL GROUPS | SANOFI (FR) | 2014-03-20 | — | — | US | disclosed |
| US-20140081019-A1 | PROCESS FOR THE PREPARATION OF DEUTERATED COMPOUNDS CONTAINING N-ALKYL GROUPS | SANOFI (FR) | 2014-03-20 | — | — | US | disclosed |
| US-20140081019-A1 | PROCESS FOR THE PREPARATION OF DEUTERATED COMPOUNDS CONTAINING N-ALKYL GROUPS | SANOFI (FR) | 2014-03-20 | — | — | US | disclosed |
| US-8536173-B2 | Tetrahydroquinoxaline urea derivatives as modulators of 11-B-hydroxysteroid dehydrogenase type I | SANOFI (FR) | 2013-09-17 | — | — | US | disclosed |
| WO-2012160015-A1 | PROCESS FOR THE PREPARATION OF DEUTERATED COMPOUNDS CONTAINING N-ALKYL GROUPS | SANOFI (FR) | 2012-11-29 | — | — | WO | disclosed |
| WO-2012160015-A1 | PROCESS FOR THE PREPARATION OF DEUTERATED COMPOUNDS CONTAINING N-ALKYL GROUPS | SANOFI (FR) | 2012-11-29 | — | — | WO | disclosed |
| US-20120165337-A1 | TETRAHYDROQUINOXALINE UREA DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-06-28 | — | — | US | disclosed |
| EP-2459548-A1 | TETRAHYDROQUINOXALINE UREA DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-06-06 | — | — | EP | disclosed |
| WO-2011012800-A1 | TETRAHYDROQUINOXALINE UREA DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2011-02-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140081019-A1 | PROCESS FOR THE PREPARATION OF DEUTERATED COMPOUNDS CONTAINING N-ALKYL GROUPS | HDHD5, DRD4, DRD2 | HSD11B1 156/4885HSD11B2 103/4885PTPN11 4672/4885 |
| US-20120165337-A1 | TETRAHYDROQUINOXALINE UREA DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | NR2C2, CBR3, NR0B2 | HSD11B1 1172/4885HSD11B2 991/4885PTPN11 2443/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.