Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDHA | P00338 | 4/20 | 0.74 |
| ▸ | NOTUM | Q6P988 | 4/20 | 0.37 |
| ▸ | CFTR | P13569 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.33 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.33 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16240283 | 0.91 | LDHA (0.79) | LDHANOTUMALDH1A1L3MBTL1MRGPRX4 | |
| SCHEMBL16240258 | 0.86 | LDHA (0.72) | LDHANOTUMALDH1A1L3MBTL1MAPT | |
| SCHEMBL15070120 | 0.85 | LDHA (1.00) | LDHANOTUMCFTRALDH1A1AR | |
| SCHEMBL16240013 | 0.85 | LDHA (0.74) | LDHAAKR1B10AKR1C4AKR1C3AKR1C2 | |
| SCHEMBL16240393 | 0.84 | LDHA (0.66) | LDHANOTUMCFTRMRGPRX4HTT | |
| SCHEMBL16240031 | 0.84 | LDHA (0.66) | LDHANOTUMMRGPRX4MAPTHTT | |
| SCHEMBL16241236 | 0.82 | LDHA (0.77) | LDHAMRGPRX4AKR1C2AKR1C1 | |
| SCHEMBL16240536 | 0.81 | LDHA (0.68) | LDHANOTUMALDH1A1MRGPRX4MAPT | |
| SCHEMBL16240287 | 0.80 | LDHA (0.76) | LDHAAR | |
| SCHEMBL16240929 | 0.77 | LDHA (0.71) | LDHAALDH1A1L3MBTL1AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140343001-A1 | INDOLE DERIVATIVES INHIBITORS OF ENZYME LACTATE DEHYDROGENASE (LDH) | UNIVERSITA DI PISA (IT) | 2014-11-20 | — | — | US | claimed |
| US-20140343001-A1 | INDOLE DERIVATIVES INHIBITORS OF ENZYME LACTATE DEHYDROGENASE (LDH) | UNIVERSITA DI PISA (IT) | 2014-11-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140343001-A1 | INDOLE DERIVATIVES INHIBITORS OF ENZYME LACTATE DEHYDROGENASE (LDH) | LDHA, LDHB, IDO1 | LDHA 1/4885NOTUM 2229/4885CFTR 4012/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.