SCHEMBL16240579

SCHEMBL16240579

CN(c1ccc(-c2ccc(Cl)cc2)cc1)[C@H]1C[C@H]([C@@](N)(CCCCB(O)O)C(=O)O)C1

nearest known ligand 0.59

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ARG1 P05089 20/20 0.59
ARG2 P78540 20/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL895289 0.92 ARG1 (0.55) ARG1ARG2
Hydrochloric Acid SCHEMBL895926 0.91 ARG1 (0.54) ARG1ARG2
SCHEMBL16240559 0.91 ARG1 (0.54) ARG1ARG2
SCHEMBL16240867 0.90 ARG1 (0.57) ARG1ARG2
SCHEMBL16240945 0.90 ARG1 (0.49) ARG1ARG2
SCHEMBL16240994 0.89 ARG1 (0.55) ARG1ARG2
SCHEMBL16240980 0.88 ARG1 (0.51) ARG1ARG2
SCHEMBL16241493 0.88 ARG1 (0.53) ARG1ARG2
SCHEMBL16240563 0.87 ARG1 (0.52) ARG1ARG2
SCHEMBL16240571 0.87 ARG1 (0.54) ARG1ARG2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2768491-B1 INHIBITORS OF ARGINASE AND THEIR THERAPEUTIC APPLICATIONS MARS INC (US) 2016-12-21 EP disclosed
US-9266908-B2 Inhibitors of arginase and their therapeutic applications MARS, INCORPORATED (US) 2016-02-23 US disclosed
US-20140343019-A1 INHIBITORS OF ARGINASE AND THEIR THERAPEUTIC APPLICATIONS MARS, INCORPORATED 2014-11-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140343019-A1 INHIBITORS OF ARGINASE AND THEIR THERAPEUTIC APPLICATIONS ARG1, ARG2, PRMT1 ARG1 1/4885ARG2 2/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.