Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDHA | P00338 | 4/20 | 0.67 |
| ▸ | SCN1A | P35498 | 6/20 | 0.52 |
| ▸ | SCN2A | Q99250 | 6/20 | 0.52 |
| ▸ | SCN3A | Q9NY46 | 6/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 5/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16241012 | 0.87 | LDHA (0.66) | LDHASCN1ASCN2ASCN3AMAPT | |
| SCHEMBL15060018 | 0.83 | LDHA (0.46) | LDHASCN1ASCN2ASCN3AKMT2A | |
| SCHEMBL15070120 | 0.81 | LDHA (1.00) | LDHAKDM4E | |
| SCHEMBL15058048 | 0.78 | LDHA (0.77) | LDHAKMT2AMEN1KDM4ELMNA | |
| SCHEMBL15058801 | 0.78 | LDHA (0.77) | LDHAKDM4EMAPTNPSR1 | |
| SCHEMBL7624 | 0.77 | LDHA (1.00) | LDHA | |
| SCHEMBL15059011 | 0.76 | LDHA (0.47) | LDHAMAPTCHRM4 | |
| SCHEMBL15058967 | 0.75 | LDHA (0.72) | LDHAKMT2AMEN1KDM4ELMNA | |
| SCHEMBL15058822 | 0.75 | LDHA (0.71) | LDHAKDM4ECHRM3CHRM4CHRM5 | |
| SCHEMBL16240841 | 0.72 | LDHA (0.46) | LDHAKMT2AMEN1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140343001-A1 | INDOLE DERIVATIVES INHIBITORS OF ENZYME LACTATE DEHYDROGENASE (LDH) | UNIVERSITA DI PISA (IT) | 2014-11-20 | — | — | US | claimed |
| US-20140343001-A1 | INDOLE DERIVATIVES INHIBITORS OF ENZYME LACTATE DEHYDROGENASE (LDH) | UNIVERSITA DI PISA (IT) | 2014-11-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140343001-A1 | INDOLE DERIVATIVES INHIBITORS OF ENZYME LACTATE DEHYDROGENASE (LDH) | LDHA, LDHB, IDO1 | LDHA 1/4885SCN1A 3172/4885SCN2A 3359/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.