SCHEMBL16242012

SCHEMBL16242012

CCOC(=O)c1nnn(-c2ccc(C(=O)OC)c(F)c2)n1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TP53 P04637 2/20 0.39
ALDH1A1 P00352 2/20 0.38
HPGD P15428 1/20 0.38
ALOX15 P16050 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38
HSD17B10 Q99714 1/20 0.38
KMT2A Q03164 3/20 0.38
JMJD6 Q6NYC1 1/20 0.38
NPC1 O15118 3/20 0.37
LMNA P02545 1/20 0.37
RAB9A P51151 1/20 0.37
HTT P42858 2/20 0.37
GRM5 P41594 1/20 0.37
THRB P10828 1/20 0.37
MYC P01106 1/20 0.36
PKM P14618 1/20 0.36
L3MBTL1 Q9Y468 2/20 0.36
MEN1 O00255 1/20 0.36
ATM Q13315 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16242063 0.87 GRM5 (0.37) TP53ALDH1A1HPGDHSD17B10KMT2A
SCHEMBL16241942 0.86 GRM5 (0.39) TP53ALDH1A1KMT2AGRM5THRB
SCHEMBL31227330 0.82 GRM5 (0.41) TP53ALDH1A1HPGDKMT2AGRM5
SCHEMBL16241897 0.81 GRM5 (0.36) TP53ALDH1A1HPGDHSD17B10KMT2A
SCHEMBL12442229 0.80 NPC1 (0.52) ALDH1A1NPSR1KMT2ANPC1LMNA
SCHEMBL16241963 0.80 TP53 (0.43) TP53ALDH1A1HPGDALOX15NPSR1
SCHEMBL16242046 0.79 GRM5 (0.36) TP53ALDH1A1KMT2ALMNAGRM5
SCHEMBL29254943 0.76 CA12 (0.49) TP53ALDH1A1HPGDKMT2ANPC1
SCHEMBL20574684 0.76 S1PR1 (0.42) ALDH1A1HPGDHSD17B10KMT2ANPC1
SCHEMBL30444564 0.76 S1PR1 (0.42) ALDH1A1HPGDHSD17B10KMT2ANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9725438-B2 Substituted phenylazole derivative DAIICHI SANKYO COMPANY, LIMITED (JP) 2017-08-08 US disclosed
US-9725438-B2 Substituted phenylazole derivative DAIICHI SANKYO COMPANY, LIMITED (JP) 2017-08-08 US disclosed
US-9725438-B2 Substituted phenylazole derivative DAIICHI SANKYO COMPANY, LIMITED (JP) 2017-08-08 US disclosed
EP-3009433-B1 2-PHENYL-1,3-OXAZOLE AND 5-PHENYL-1,2,4-OXADIAZOLE DERIVATIVES FOR THE TREATMENT OF DIABETES DAIICHI SANKYO CO LTD (JP) 2017-06-21 EP disclosed
EP-2805941-B1 SUBSTITUTED PHENYLAZOLE DERIVATIVE DAIICHI SANKYO CO LTD (JP) 2016-08-17 EP disclosed
EP-3009433-A1 2-PHENYL-1,3-OXAZOLE AND 5-PHENYL-1,2,4-OXADIAZOLE DERIVATIVES FOR THE TREATMENT OF DIABETES Daiichi Sankyo Company, Limited (JP) 2016-04-20 EP disclosed
US-20160090375-A1 SUBSTITUTED PHENYLAZOLE DERIVATIVE DAIICHI SANKYO COMPANY, LIMITED (JP) 2016-03-31 US disclosed
US-20160090375-A1 SUBSTITUTED PHENYLAZOLE DERIVATIVE DAIICHI SANKYO COMPANY, LIMITED (JP) 2016-03-31 US disclosed
US-20160090375-A1 SUBSTITUTED PHENYLAZOLE DERIVATIVE DAIICHI SANKYO COMPANY, LIMITED (JP) 2016-03-31 US disclosed
US-20160081993-A1 SUBSTITUTED PHENYLAZOLE DERIVATIVE DAIICHI SANKYO COMPANY, LIMITED (JP) 2016-03-24 US disclosed
US-20160081993-A1 SUBSTITUTED PHENYLAZOLE DERIVATIVE DAIICHI SANKYO COMPANY, LIMITED (JP) 2016-03-24 US disclosed
US-20160081993-A1 SUBSTITUTED PHENYLAZOLE DERIVATIVE DAIICHI SANKYO COMPANY, LIMITED (JP) 2016-03-24 US disclosed
US-9233958-B2 Substituted phenylazole derivatives DAIICHI SANKYO COMPANY, LIMITED (JP) 2016-01-12 US disclosed
US-9233958-B2 Substituted phenylazole derivatives DAIICHI SANKYO COMPANY, LIMITED (JP) 2016-01-12 US disclosed
US-9233958-B2 Substituted phenylazole derivatives DAIICHI SANKYO COMPANY, LIMITED (JP) 2016-01-12 US disclosed
US-20140357675-A1 Substituted Phenylazole Derivatives DAIICHI SANKYO COMPANY, LIMITED (JP) 2014-12-04 US disclosed
US-20140357675-A1 Substituted Phenylazole Derivatives DAIICHI SANKYO COMPANY, LIMITED (JP) 2014-12-04 US disclosed
US-20140357675-A1 Substituted Phenylazole Derivatives DAIICHI SANKYO COMPANY, LIMITED (JP) 2014-12-04 US disclosed
EP-2805941-A1 SUBSTITUTED PHENYLAZOLE DERIVATIVE DAIICHI SANKYO COMPANY, LIMITED (JP) 2014-11-26 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160081993-A1 SUBSTITUTED PHENYLAZOLE DERIVATIVE IAPP, SLC5A1, GPR119 TP53 1112/4885ALDH1A1 422/4885HPGD 2014/4885
US-20160090375-A1 SUBSTITUTED PHENYLAZOLE DERIVATIVE IAPP, SLC5A1, GPR119 TP53 1112/4885ALDH1A1 422/4885HPGD 2014/4885
US-20140357675-A1 Substituted Phenylazole Derivatives IAPP, SLC5A1, GPR119 TP53 1059/4885ALDH1A1 407/4885HPGD 2122/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.