SCHEMBL16241963

SCHEMBL16241963

CCOC(=O)c1cnn(-c2ccc(C(=O)OC)c(F)c2)n1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TP53 P04637 2/20 0.43
JMJD6 Q6NYC1 1/20 0.40
GABRA2 P47869 1/20 0.39
GABRB2 P47870 1/20 0.39
ALDH1A1 P00352 3/20 0.38
HPGD P15428 1/20 0.38
ALOX15 P16050 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38
HSD17B10 Q99714 1/20 0.38
RAB9A P51151 4/20 0.38
NPC1 O15118 4/20 0.38
SMN1; SMN2 Q16637 3/20 0.38
LMNA P02545 2/20 0.37
CHRNA7 P36544 1/20 0.37
TSHR P16473 1/20 0.37
KDM4E B2RXH2 1/20 0.37
HTT P42858 1/20 0.37
THRB P10828 1/20 0.37
KMT2A Q03164 2/20 0.36
MYC P01106 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16242007 0.87 TP53 (0.35) TP53ALDH1A1HPGDALOX15NPSR1
SCHEMBL23354918 0.87 ALDH1A1 (0.49) TP53JMJD6GABRA2GABRB2ALDH1A1
SCHEMBL16242073 0.86 KDM4E (0.37) TP53ALDH1A1ALOX15RAB9ANPC1
SCHEMBL16242077 0.86 MYC (0.36) TP53ALDH1A1HPGDALOX15HSD17B10
SCHEMBL23354916 0.84 NOTUM (0.47) TP53JMJD6GABRA2GABRB2ALDH1A1
SCHEMBL16242095 0.82 PIK3CA (0.35) TP53ALDH1A1ALOX15TSHRKDM4E
SCHEMBL23354747 0.82 ALDH1A1 (0.39) TP53JMJD6GABRA2GABRB2ALDH1A1
SCHEMBL23354837 0.82 TP53 (0.41) TP53JMJD6GABRA2GABRB2ALDH1A1
SCHEMBL23354902 0.81 NOTUM (0.47) TP53GABRA2GABRB2ALDH1A1RAB9A
SCHEMBL23354760 0.80 GABRA2 (0.54) TP53GABRA2GABRB2ALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9725438-B2 Substituted phenylazole derivative DAIICHI SANKYO COMPANY, LIMITED (JP) 2017-08-08 US disclosed
US-9725438-B2 Substituted phenylazole derivative DAIICHI SANKYO COMPANY, LIMITED (JP) 2017-08-08 US disclosed
US-9725438-B2 Substituted phenylazole derivative DAIICHI SANKYO COMPANY, LIMITED (JP) 2017-08-08 US disclosed
EP-3009433-B1 2-PHENYL-1,3-OXAZOLE AND 5-PHENYL-1,2,4-OXADIAZOLE DERIVATIVES FOR THE TREATMENT OF DIABETES DAIICHI SANKYO CO LTD (JP) 2017-06-21 EP disclosed
EP-2805941-B1 SUBSTITUTED PHENYLAZOLE DERIVATIVE DAIICHI SANKYO CO LTD (JP) 2016-08-17 EP disclosed
EP-3009433-A1 2-PHENYL-1,3-OXAZOLE AND 5-PHENYL-1,2,4-OXADIAZOLE DERIVATIVES FOR THE TREATMENT OF DIABETES Daiichi Sankyo Company, Limited (JP) 2016-04-20 EP disclosed
US-20160090375-A1 SUBSTITUTED PHENYLAZOLE DERIVATIVE DAIICHI SANKYO COMPANY, LIMITED (JP) 2016-03-31 US disclosed
US-20160090375-A1 SUBSTITUTED PHENYLAZOLE DERIVATIVE DAIICHI SANKYO COMPANY, LIMITED (JP) 2016-03-31 US disclosed
US-20160090375-A1 SUBSTITUTED PHENYLAZOLE DERIVATIVE DAIICHI SANKYO COMPANY, LIMITED (JP) 2016-03-31 US disclosed
US-20160081993-A1 SUBSTITUTED PHENYLAZOLE DERIVATIVE DAIICHI SANKYO COMPANY, LIMITED (JP) 2016-03-24 US disclosed
US-20160081993-A1 SUBSTITUTED PHENYLAZOLE DERIVATIVE DAIICHI SANKYO COMPANY, LIMITED (JP) 2016-03-24 US disclosed
US-20160081993-A1 SUBSTITUTED PHENYLAZOLE DERIVATIVE DAIICHI SANKYO COMPANY, LIMITED (JP) 2016-03-24 US disclosed
US-9233958-B2 Substituted phenylazole derivatives DAIICHI SANKYO COMPANY, LIMITED (JP) 2016-01-12 US disclosed
US-9233958-B2 Substituted phenylazole derivatives DAIICHI SANKYO COMPANY, LIMITED (JP) 2016-01-12 US disclosed
US-9233958-B2 Substituted phenylazole derivatives DAIICHI SANKYO COMPANY, LIMITED (JP) 2016-01-12 US disclosed
US-20140357675-A1 Substituted Phenylazole Derivatives DAIICHI SANKYO COMPANY, LIMITED (JP) 2014-12-04 US disclosed
US-20140357675-A1 Substituted Phenylazole Derivatives DAIICHI SANKYO COMPANY, LIMITED (JP) 2014-12-04 US disclosed
US-20140357675-A1 Substituted Phenylazole Derivatives DAIICHI SANKYO COMPANY, LIMITED (JP) 2014-12-04 US disclosed
EP-2805941-A1 SUBSTITUTED PHENYLAZOLE DERIVATIVE DAIICHI SANKYO COMPANY, LIMITED (JP) 2014-11-26 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160081993-A1 SUBSTITUTED PHENYLAZOLE DERIVATIVE IAPP, SLC5A1, GPR119 TP53 1112/4885JMJD6 4438/4885GABRA2 1706/4885
US-20160090375-A1 SUBSTITUTED PHENYLAZOLE DERIVATIVE IAPP, SLC5A1, GPR119 TP53 1112/4885JMJD6 4438/4885GABRA2 1706/4885
US-20140357675-A1 Substituted Phenylazole Derivatives IAPP, SLC5A1, GPR119 TP53 1059/4885JMJD6 4415/4885GABRA2 1521/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.