Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STK17B | O94768 | 1/20 | 0.50 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.50 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | JAK3 | P52333 | 3/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 8/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.36 |
| ▸ | JAK2 | O60674 | 8/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 7/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 7/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 7/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 7/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 7/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 7/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16245551 | 0.86 | STK17B (0.53) | STK17BSTK17AJAK3BTKHDAC3 | |
| SCHEMBL18869378 | 0.84 | STK17B (0.52) | STK17BSTK17AJAK3BTKHDAC3 | |
| SCHEMBL17827718 | 0.83 | STK17B (0.46) | STK17BSTK17APIN1MAPTLMNA | |
| SCHEMBL29802555 | 0.80 | STK17A (0.72) | STK17BSTK17APIN1BRD4MEN1 | |
| SCHEMBL16245575 | 0.80 | PIN1 (0.50) | PIN1MAPTJAK3LMNAHTT | |
| SCHEMBL16245576 | 0.79 | EGFR (0.46) | MAPTJAK3HDAC3HDAC8JAK2 | |
| SCHEMBL12968578 | 0.78 | STK17A (0.62) | STK17BSTK17APIN1MAPTBRD4 | |
| SCHEMBL16245917 | 0.77 | PIN1 (0.55) | STK17BSTK17APIN1MAPTBRD4 | |
| SCHEMBL16012447 | 0.77 | PIN1 (0.58) | PIN1MAPTJAK3LMNAJAK2 | |
| SCHEMBL16264881 | 0.76 | ALDH1A1 (0.48) | STK17BSTK17AMAPTLMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9861635-B2 | Macrocycles as kinase inhibitors | MERCK PATENT GMBH (DE) | 2018-01-09 | — | — | US | disclosed |
| US-9861635-B2 | Macrocycles as kinase inhibitors | MERCK PATENT GMBH (DE) | 2018-01-09 | — | — | US | disclosed |
| EP-2994471-B1 | MACROCYCLES AS KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2017-05-17 | — | — | EP | disclosed |
| US-20160166574-A1 | MACROCYCLES AS KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2016-06-16 | — | — | US | disclosed |
| US-20160166574-A1 | MACROCYCLES AS KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2016-06-16 | — | — | US | disclosed |
| EP-2994471-A1 | MACROCYCLES AS KINASE INHIBITORS | Merck Patent GmbH (DE) | 2016-03-16 | — | — | EP | disclosed |
| WO-2014180524-A1 | MACROCYCLES AS KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2014-11-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160166574-A1 | MACROCYCLES AS KINASE INHIBITORS | EIF2AK4, CDK2, CDK1 | STK17B 214/4885STK17A 246/4885PIN1 1347/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.