Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16246265 | 0.85 | MAPT (0.56) | POLBKMT2AALDH1A1LMNAMAPT | |
| SCHEMBL16387392 | 0.78 | FLT3 (0.51) | POLBKMT2AALDH1A1MAPTTP53 | |
| SCHEMBL16263888 | 0.77 | CNR2 (0.51) | KMT2AALDH1A1MAPTTP53TSHR | |
| SCHEMBL16263777 | 0.75 | CNR2 (0.51) | KMT2AALDH1A1MAPTTP53TSHR | |
| SCHEMBL16246529 | 0.72 | MAPT (0.45) | KMT2AL3MBTL1ALDH1A1LMNAMAPT | |
| SCHEMBL28157400 | 0.68 | MAPT (0.60) | POLBKMT2AALDH1A1MAPTTP53 | |
| SCHEMBL16246474 | 0.65 | MAPT (0.59) | POLBKMT2AALDH1A1LMNAMAPT | |
| SCHEMBL28157299 | 0.63 | MAPT (0.66) | POLBKMT2AALDH1A1MAPTTP53 | |
| SCHEMBL16088763 | 0.63 | MAPT (0.62) | POLBKMT2AALDH1A1LMNAMAPT | |
| SCHEMBL3343329 | 0.62 | PKM (0.58) | POLBKMT2AL3MBTL1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2994463-A1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF CYSTIC FIBROSIS | Galapagos NV (BE) | 2016-03-16 | — | — | EP | disclosed |
| WO-2014180562-A1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF CYSTIC FIBROSIS | GALAPAGOS NV (BE) | 2014-11-13 | — | — | WO | disclosed |