Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC5 | P28715 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.37 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.37 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL162291 | 0.85 | XDH (0.43) | ERCC5FEN1CSNK2A1ALDH1A1MAPT | |
| SCHEMBL164309 | 0.82 | ERCC5 (0.40) | ERCC5FEN1CYP3A4CSNK2A1LOXL2 | |
| SCHEMBL160755 | 0.81 | ERCC5 (0.41) | ERCC5FEN1CYP3A4CSNK2A1LOXL2 | |
| SCHEMBL161347 | 0.81 | DGAT1 (0.54) | MAPTSMN1; SMN2LMNAHDAC6 | |
| SCHEMBL163569 | 0.80 | PTPN1 (0.48) | CSNK2A1SMN1; SMN2CSNK2A2 | |
| SCHEMBL161029 | 0.79 | ERCC5 (0.39) | ERCC5FEN1CYP3A4CSNK2A1LOXL2 | |
| SCHEMBL160763 | 0.78 | DGAT1 (0.53) | CYP3A4MAPTNPC1RAB9AMEN1 | |
| SCHEMBL164942 | 0.77 | DGAT1 (0.55) | MAPTNPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL160848 | 0.77 | ERCC5 (0.38) | ERCC5FEN1CYP3A4CSNK2A1LOXL2 | |
| SCHEMBL163068 | 0.76 | TRPV1 (0.45) | ALDH1A1MAPTNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611783-A2 | HETEROCYCLIC COMPOUNDS AS DGAT1 INHIBITORS | Piramal Enterprises Limited (IN) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012029032-A2 | HETEROCYCLIC COMPOUNDS AS DGAT1 INHIBITORS | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2012-03-08 | — | — | WO | disclosed |