Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 2/20 | 0.49 |
| ▸ | CCNC | P24863 | 1/20 | 0.49 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | GAK | O14976 | 1/20 | 0.42 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.39 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.39 |
| ▸ | FERMT2 | Q96AC1 | 1/20 | 0.38 |
| ▸ | USP10 | Q14694 | 1/20 | 0.38 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.38 |
| ▸ | USP13 | Q92995 | 1/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 2/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | NCF1 | P14598 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2326429 | 0.77 | CCR1 (0.50) | CDK8CCNCCYP11B2PARP1GAK | |
| SCHEMBL16248020 | 0.77 | CCNC (0.49) | CDK8CCNCPARP1GAKSLC22A12 | |
| SCHEMBL30632276 | 0.77 | CDK8 (0.46) | CDK8CCNCCYP11B2PARP1GAK | |
| SCHEMBL17693565 | 0.76 | MAPT (0.46) | PARP1SLC22A12KDM4EMAPTNCF1 | |
| SCHEMBL16247955 | 0.76 | SLC22A12 (0.49) | CDK8CCNCGAKSLC22A12ACVR1 | |
| SCHEMBL18970831 | 0.76 | PARP1 (0.44) | CDK8CCNCCYP11B2PARP1GAK | |
| SCHEMBL29373276 | 0.76 | CDK8 (0.49) | CDK8CCNCCYP11B2PARP1GAK | |
| SCHEMBL16705385 | 0.76 | CDK8 (0.49) | CDK8CCNCCYP11B2PARP1GAK | |
| SCHEMBL16289172 | 0.76 | CDK8 (0.49) | CDK8CCNCCYP11B2PARP1GAK | |
| SCHEMBL591523 | 0.76 | CDK8 (0.49) | CDK8CCNCCYP11B2PARP1GAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109575022-B | Compound and application thereof | 成都海博锐药业有限公司 | 2021-09-21 | — | — | CN | disclosed |
| EP-2998296-B1 | CYCLOALKYL ACID DERIVATIVE, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL APPLICATION THEREOF | Shanghai hengrui pharmaceutical co ltd (CN) | 2018-03-14 | — | — | EP | disclosed |
| US-9637484-B2 | Cycloalkyl acid derivative, preparation method thereof, and pharmaceutical application thereof | SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD. (CN) | 2017-05-02 | — | — | US | disclosed |
| US-9637484-B2 | Cycloalkyl acid derivative, preparation method thereof, and pharmaceutical application thereof | SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD. (CN) | 2017-05-02 | — | — | US | disclosed |
| US-9637484-B2 | Cycloalkyl acid derivative, preparation method thereof, and pharmaceutical application thereof | SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD. (CN) | 2017-05-02 | — | — | US | disclosed |
| US-20160108035-A1 | CYCLOALKYL ACID DERIVATIVE, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL APPLICATION THEREOF | Shanghai Hengrui Pharmaceutical Co., Lt.d (CN) | 2016-04-21 | — | — | US | disclosed |
| US-20160108035-A1 | CYCLOALKYL ACID DERIVATIVE, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL APPLICATION THEREOF | Shanghai Hengrui Pharmaceutical Co., Lt.d (CN) | 2016-04-21 | — | — | US | disclosed |
| US-20160108035-A1 | CYCLOALKYL ACID DERIVATIVE, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL APPLICATION THEREOF | Shanghai Hengrui Pharmaceutical Co., Lt.d (CN) | 2016-04-21 | — | — | US | disclosed |
| EP-2998296-A1 | CYCLOALKYL ACID DERIVATIVE, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL APPLICATION THEREOF | Shanghai Hengrui Pharmaceutical Co. Ltd. (CN) | 2016-03-23 | — | — | EP | disclosed |
| EP-2998296-A1 | CYCLOALKYL ACID DERIVATIVE, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL APPLICATION THEREOF | Shanghai Hengrui Pharmaceutical Co. Ltd. (CN) | 2016-03-23 | — | — | EP | disclosed |
| WO-2014183555-A1 | CYCLOALKYL ACID DERIVATIVE, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL APPLICATION THEREOF | 上海恒瑞医药有限公司 (CN) | 2014-11-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160108035-A1 | CYCLOALKYL ACID DERIVATIVE, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL APPLICATION THEREOF | UGP2, MPST, KYAT1 | CDK8 3658/4885CCNC 4760/4885CYP11B2 1048/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.