Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 9/20 | 0.67 |
| ▸ | DRD2 | P14416 | 8/20 | 0.67 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.62 |
| ▸ | BACE1 | P56817 | 2/20 | 0.61 |
| ▸ | BCHE | P06276 | 1/20 | 0.61 |
| ▸ | ACHE | P22303 | 1/20 | 0.61 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.60 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.60 |
| ▸ | DRD3 | P35462 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | MC4R | P32245 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19614234 | 0.97 | DRD4 (0.70) | DRD4DRD2SIGMAR1BACE1BCHE | |
| SCHEMBL20183285 | 0.97 | DRD4 (0.70) | DRD4DRD2SIGMAR1BACE1BCHE | |
| SCHEMBL17961749 | 0.97 | DRD4 (0.70) | DRD4DRD2SIGMAR1BACE1BCHE | |
| SCHEMBL5143427 | 0.91 | ALDH1A1 (0.60) | DRD4DRD2BCHEDPP7DRD3 | |
| SCHEMBL1623588 | 0.91 | ALDH1A1 (0.60) | DRD4DRD2BCHEDPP7DRD3 | |
| SCHEMBL239527 | 0.90 | DRD4 (0.71) | DRD4DRD2SIGMAR1BACE1BCHE | |
| SCHEMBL239528 | 0.90 | DRD4 (0.71) | DRD4DRD2SIGMAR1BACE1BCHE | |
| SCHEMBL2425554 | 0.88 | SIGMAR1 (0.78) | DRD4DRD2SIGMAR1DPP7MCHR1 | |
| Hydrochloric Acid SCHEMBL21410212 | 0.87 | SIGMAR1 (0.76) | DRD4DRD2SIGMAR1DPP7MCHR1 | |
| SCHEMBL1720926 | 0.86 | SIGMAR1 (0.62) | DRD4DRD2SIGMAR1BACE1BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7928107-B2 | Quinazolines useful as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-04-19 | — | — | US | disclosed |