Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.37 |
| ▸ | CASP6 | P55212 | 1/20 | 0.37 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.37 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 5/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7307900 | 0.81 | ALDH1A1 (0.43) | SMN1; SMN2ALDH1A1MAPK1KDM4EMAPT | |
| SCHEMBL20708377 | 0.79 | LMNA (0.39) | SMN1; SMN2ALDH1A1MAPK1KDM4ETDP1 | |
| SCHEMBL11082976 | 0.77 | SMN1; SMN2 (0.37) | SMN1; SMN2ALDH1A1MAPK1KDM4EMAPT | |
| SCHEMBL18231695 | 0.75 | MAPK1 (0.39) | ALDH1A1MAPK1LMNA | |
| SCHEMBL4097495 | 0.75 | TSHR (0.39) | SMN1; SMN2ALDH1A1MAPK1KDM4EHPGD | |
| SCHEMBL17818836 | 0.75 | SMN1; SMN2 (0.36) | SMN1; SMN2ALDH1A1MAPK1KDM4EMAPT | |
| SCHEMBL14176733 | 0.74 | GAA (0.41) | SMN1; SMN2ALDH1A1MAPK1KDM4EMAPT | |
| SCHEMBL22223973 | 0.71 | SMN1; SMN2 (0.35) | SMN1; SMN2ALDH1A1MAPK1KDM4EMAPT | |
| SCHEMBL11939846 | 0.69 | GAA (0.41) | SMN1; SMN2ALDH1A1MAPK1KDM4EMAPT | |
| SCHEMBL29889521 | 0.67 | ALDH1A1 (0.40) | ALDH1A1LMNAMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140343085-A1 | USE OF ARYL DERIVATIVES FOR CONTROLLING ECTOPARASITES | NOVARTIS AG (CH) | 2014-11-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140343085-A1 | USE OF ARYL DERIVATIVES FOR CONTROLLING ECTOPARASITES | TYR, CYP2E1, CYP3A43 | SMN1; SMN2 3718/4885ALDH1A1 256/4885MAPK1 939/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.